Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6547166 | 0.84 | PTGER1 (0.38) | PTGER1PTGER4PTGER3PTGER2FABP4 | |
| SCHEMBL6547635 | 0.81 | TLR8 (0.43) | PTGER1PTGER4PTGER3PTGER2FABP4 | |
| SCHEMBL3165882 | 0.81 | ALDH1A1 (0.46) | PTGER1PTGER4PTGER3PTGER2PTPN1 | |
| SCHEMBL4078766 | 0.81 | ALDH1A1 (0.46) | PTGER1PTGER4PTGER3PTGER2PTPN1 | |
| SCHEMBL29285198 | 0.79 | PDCD1 (0.51) | PDCD1CD274 | |
| SCHEMBL29285199 | 0.79 | PDCD1 (0.51) | PDCD1CD274 | |
| SCHEMBL6546792 | 0.78 | PTGS1 (0.40) | FABP4CASP1RPA1MCL1FGFR1 | |
| SCHEMBL6546806 | 0.78 | PTGS1 (0.40) | FABP4CASP1RPA1MCL1FGFR1 | |
| SCHEMBL27994690 | 0.78 | TRPA1 (0.40) | PTGER1PTGER4PTGER3PTGER2PTPN1 | |
| SCHEMBL9818110 | 0.76 | CA1 (0.53) | PTGER1PTGER4PTGER3PTGER2FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972294-B1 | Compounds, their preparation and use | NOVO NORDISK, A/S (DK) | 2005-12-06 | — | — | US | disclosed |
| EP-1171414-A1 | COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000063153-A1 | NEW COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |