SCHEMBL6441245

SCHEMBL6441245

COC(=O)c1n[nH]c(-c2ccc(SC)cc2)c1-c1ccc(OC)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.45
LMNA P02545 3/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
ALPL P05186 1/20 0.45
RAB9A P51151 1/20 0.45
GSK3B P49841 1/20 0.44
UBE2N P61088 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
HTT P42858 1/20 0.43
MAPK10 P53779 1/20 0.43
ALDH1A1 P00352 4/20 0.41
KDM4E B2RXH2 2/20 0.41
PKM P14618 1/20 0.41
PRKAG1 P54619 1/20 0.40
PRKAA1 Q13131 1/20 0.40
PRKAB1 Q9Y478 1/20 0.40
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
PSMD14 O00487 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6441497 0.89 ALDH1A1 (0.53) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL6439608 0.88 MAPT (0.45) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL6440359 0.88 ALDH1A1 (0.41) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL6441172 0.88 ALDH1A1 (0.41) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL5150566 0.85 ALDH1A1 (0.39) MAPTLMNASMN1; SMN2NPC1L3MBTL1
SCHEMBL6444469 0.85 ALDH1A1 (0.41) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL6440017 0.80 TGFBR1 (0.44) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL28180319 0.76 ALDH1A1 (0.45) MAPTLMNASMN1; SMN2NPC1ALPL
SCHEMBL8196145 0.75 CYP1A1 (0.40) MAPTLMNASMN1; SMN2NPC1ALPL
SCHEMBL5150592 0.73 ALDH1A1 (0.36) MAPTLMNASMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534683-A4 CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2005-08-24 EP disclosed
EP-1534683-A2 CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2005-06-01 EP disclosed
WO-2004002409-A2 CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2004-01-08 WO disclosed