Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | DUT | P33316 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745770 | 0.84 | SMN1; SMN2 (0.45) | MEN1KMT2AMAOAHTT | |
| SCHEMBL5746437 | 0.82 | TLR4 (0.41) | ALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL6443197 | 0.82 | CNR1 (0.43) | GAAMEN1KMT2AMAOAHTT | |
| SCHEMBL6444773 | 0.82 | NPC1 (0.47) | KMT2ANPC1RAB9AMAOACASR | |
| SCHEMBL27550269 | 0.81 | ALDH1A1 (0.39) | ALDH1A1GAAMEN1KMT2ACHRNB2 | |
| SCHEMBL6440316 | 0.79 | SMPD1 (0.41) | KMT2ARAB9AMAOA | |
| SCHEMBL6443205 | 0.78 | MAPK9 (0.34) | GAAMEN1KMT2AADRB2ADRB1 | |
| SCHEMBL6025036 | 0.78 | GAA (0.38) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6024314 | 0.78 | MAPK9 (0.34) | ALDH1A1GAAMEN1KMT2ANPC1 | |
| SCHEMBL6024760 | 0.78 | MAPK9 (0.34) | GAAMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499577-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003087026-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | WO | disclosed |