Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP27B1 | O15528 | 1/20 | 0.36 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745770 | 0.91 | SMN1; SMN2 (0.45) | MAOBBCHEALOX5MAOASLC2A1 | |
| SCHEMBL6443197 | 0.90 | CNR1 (0.43) | TLR4TLR2SMPD1MAOBALOX5 | |
| SCHEMBL6440316 | 0.88 | SMPD1 (0.41) | RAB9ASMPD1MAOBMAOAKMT2A | |
| SCHEMBL5747030 | 0.85 | GPR132 (0.43) | — | |
| SCHEMBL5746437 | 0.83 | TLR4 (0.41) | TLR4TLR2MAOAKMT2ASMN1; SMN2 | |
| SCHEMBL6441296 | 0.82 | ALDH1A1 (0.40) | NPC1RAB9AMAOAKMT2ACASR | |
| SCHEMBL6443205 | 0.78 | MAPK9 (0.34) | NPC1RAB9AKMT2A | |
| SCHEMBL6025036 | 0.75 | GAA (0.38) | NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL6024760 | 0.75 | MAPK9 (0.34) | NPC1RAB9AKMT2A | |
| SCHEMBL6024314 | 0.75 | MAPK9 (0.34) | NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499577-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003087026-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | WO | disclosed |