Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745770 | 0.88 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2AMAOA | |
| SCHEMBL6443197 | 0.83 | CNR1 (0.43) | TLR4TLR2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6444773 | 0.83 | NPC1 (0.47) | TLR4TLR2SMN1; SMN2KMT2AMAOA | |
| SCHEMBL6441296 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL5747030 | 0.82 | GPR132 (0.43) | GPR132 | |
| SCHEMBL6440316 | 0.81 | SMPD1 (0.41) | SMN1; SMN2KMT2AMAOA | |
| SCHEMBL6443205 | 0.78 | MAPK9 (0.34) | KDM4EMEN1KMT2AMAPTHTR1A | |
| SCHEMBL7253009 | 0.78 | MEN1 (0.41) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL6025036 | 0.76 | GAA (0.38) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6024314 | 0.76 | MAPK9 (0.34) | ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675848-A1 | NOVEL TRIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005040153-A1 | NOVEL TRIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |