Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 7/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745770 | 0.88 | SMN1; SMN2 (0.45) | MAOBMAOASGMS2KMT2ASMN1; SMN2 | |
| SCHEMBL6443197 | 0.88 | CNR1 (0.43) | SMPD1MAOBMAOAKMT2ASMN1; SMN2 | |
| SCHEMBL6444773 | 0.88 | NPC1 (0.47) | SMPD1MAOBMAOARAB9AKMT2A | |
| SCHEMBL5747030 | 0.83 | GPR132 (0.43) | — | |
| SCHEMBL5746437 | 0.81 | TLR4 (0.41) | MAOAKMT2ASMN1; SMN2 | |
| SCHEMBL6441296 | 0.79 | ALDH1A1 (0.40) | MAOARAB9AKMT2A | |
| SCHEMBL27548592 | 0.78 | SMPD1 (0.45) | SMPD1CYP11B1CYP11B2CYP3A4CYP26A1 | |
| SCHEMBL27548614 | 0.76 | SMPD1 (0.42) | SMPD1CYP11B1CYP11B2CYP3A4CYP26A1 | |
| SCHEMBL6443205 | 0.75 | MAPK9 (0.34) | RAB9AKMT2A | |
| SCHEMBL6444776 | 0.75 | KEAP1 (0.41) | RAB9AACHEKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499577-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003087026-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | WO | disclosed |