Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 4/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24979083 | 0.70 | ACHE (0.46) | HSD17B10ALOX15ALDH1A1CYP1A2 | |
| SCHEMBL30162178 | 0.70 | ACHE (0.46) | HSD17B10ALOX15ALDH1A1CYP1A2 | |
| SCHEMBL28877816 | 0.68 | DHFR (0.41) | HRH3HRH2HSD17B10USP2GAA | |
| SCHEMBL29974011 | 0.68 | DHFR (0.41) | HRH3HRH2HSD17B10USP2GAA | |
| SCHEMBL26978231 | 0.67 | CCR2 (0.32) | CCR2 | |
| SCHEMBL27457600 | 0.67 | PDE10A (0.52) | HRH3HRH2HSD17B10USP2GAA | |
| SCHEMBL19174177 | 0.67 | LMNA (0.39) | HRH3HRH2HSD17B10USP2GAA | |
| SCHEMBL24978158 | 0.66 | GAA (0.38) | HRH3HRH2USP2GAAMAPT | |
| SCHEMBL23264225 | 0.66 | PKM (0.34) | — | |
| SCHEMBL13653845 | 0.66 | HEXA (0.41) | SMN1; SMN2DHFRTLR8TLR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499598-A1 | CHEMICAL COMPOUNDS WITH DUAL ACTIVITY, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | UCB, S.A. (BE) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003087064-A1 | CHEMICAL COMPOUNDS WITH DUAL ACTIVITY, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | UCB, S.A. (BE) | 2003-10-23 | — | — | WO | disclosed |