Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 4/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 4/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | RRM1 | P23921 | 1/20 | 0.32 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28755485 | 0.88 | HRH4 (0.37) | HRH4MAOAMAOBALPLAPP | |
| SCHEMBL12868653 | 0.82 | HRH4 (0.43) | HRH4MAOAMAOBALPLSLC6A4 | |
| SCHEMBL13331730 | 0.81 | LPAR1 (0.41) | APLNR | |
| SCHEMBL27757778 | 0.81 | HRH4 (0.42) | HRH4MAOAMAOBALPLAPP | |
| SCHEMBL27624241 | 0.78 | KCNK3 (0.44) | APPSLC6A4KCNK3KCNK9 | |
| SCHEMBL24221050 | 0.77 | HRH4 (0.40) | HRH4MAOAMAOBALPLSLC6A4 | |
| SCHEMBL6442565 | 0.74 | MAOA (0.37) | HRH4MAOAMAOBALPLSLC6A4 | |
| SCHEMBL27747529 | 0.74 | APLNR (0.48) | APLNR | |
| SCHEMBL28758201 | 0.73 | APP (0.37) | ALPLAPPSLC6A4 | |
| SCHEMBL21735199 | 0.72 | ALPL (0.39) | HRH4MAOAMAOBALPLKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432693-A2 | MCH RECEPTOR ANTAGONISTS | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028641-A2 | MCH RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2003-04-10 | — | — | WO | disclosed |