SCHEMBL408055

SCHEMBL408055

O=Cc1cc(Br)ccc1OC(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.51
ERN1 O75460 3/20 0.47
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
CYP2A6 P11509 2/20 0.38
ALPL P05186 4/20 0.36
TDP1 Q9NUW8 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPK1 P28482 1/20 0.35
KDR P35968 1/20 0.35
EPHX2 P34913 1/20 0.35
PTPN1 P18031 1/20 0.35
TSHR P16473 2/20 0.35
POLB P06746 1/20 0.35
CTDSP1 Q9GZU7 1/20 0.35
EPAS1 Q99814 1/20 0.35
PRKDC P78527 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29377196 1.00 PTGDR2 (0.51) PTGDR2ERN1MAOAMAOBCYP2A6
SCHEMBL2535068 0.86 PTGDR2 (0.43) PTGDR2ERN1MAOAMAOBALPL
SCHEMBL207935 0.86 MAOA (0.52) PTGDR2ERN1MAOAMAOBCYP2A6
SCHEMBL12225949 0.84 PTGDR2 (0.44) PTGDR2ERN1MAOAMAOBALDH1A1
SCHEMBL16955034 0.82 MAOA (0.43) PTGDR2ERN1MAOAMAOBALPL
SCHEMBL16953938 0.82 MAOA (0.40) PTGDR2MAOAMAOBALPLTDP1
SCHEMBL6500895 0.80 GPR3 (0.42) ERN1ALDH1A1MAPK1EPHX2POLB
SCHEMBL27391967 0.79 EPHX2 (0.33) PTGDR2TDP1ALDH1A1EPHX2TSHR
SCHEMBL2534007 0.79 PTGDR2 (0.49) PTGDR2MAOAMAOBALDH1A1PTPN1
SCHEMBL21266933 0.79 ALDH1A1 (0.41) ERN1CYP2A6TDP1ALDH1A1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3558298-B1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS MERCK SHARP & DOHME LLC (US) 2026-03-11 EP disclosed
US-20250223281-A1 ANTIDIABETIC COMPOUNDS AND COMPOSITIONS REZUBIO PHARMACEUTICALS CO., LTD (CN) 2025-07-10 US disclosed
US-20250214951-A1 3-PHENYLISOXAZOLE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING EYE DISEASE, CONTAINING SAME AS ACTIVE INGREDIENT VASTHERA CO., LTD. (KR) 2025-07-03 US disclosed
US-20250073338-A1 CONJUGATE COMPOUNDS AND COMPOSITIONS REZUBIO PHARMACEUTICALS CO., LTD (CN) 2025-03-06 US disclosed
US-20240002354-A1 ANTIDIABETIC COMPOUNDS AND COMPOSITIONS REZUBIO PHARMACEUTICALS CO., LTD (CN) 2024-01-04 US disclosed
WO-2023182871-A1 3-PHENYLISOXAZOLE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING EYE DISEASE, CONTAINING SAME AS ACTIVE INGREDIENT 바스테라 주식회사 2023-09-28 WO disclosed
CN-116472273-A Antidiabetic compounds and compositions 宁康瑞珠生物制药(珠海)有限公司 2023-07-21 CN disclosed
US-10968232-B2 Antidiabetic spirochroman compounds MERCK SHARP & DOHME CORP. (US) 2021-04-06 US disclosed
US-20190337961-A1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2019-11-07 US disclosed
EP-3558298-A1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS Merck Sharp & Dohme Corp. (US) 2019-10-30 EP disclosed
US-20110275515-A1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA CROP PROTECTION, LLC (US) 2011-11-10 US disclosed
US-D646956-S1 TV mount LEUNG ALEX 2011-10-18 US disclosed
WO-2010136431-A9 SPIRO EPOXIDES AS INTERMEDIATES SYNGENTA LIMITED (GB) 2011-03-10 WO disclosed
WO-2010136431-A1 SPIRO EPOXIDES AS INTERMEDIATES SYNGENTA LIMITED (GB) 2010-12-02 WO disclosed
WO-2010102848-A1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LIMITED (GB) 2010-09-16 WO disclosed
WO-2010081894-A1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LIMITED (GB) 2010-07-22 WO disclosed
WO-2010081755-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2010-07-22 WO disclosed
EP-1910292-A1 PIPERIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST Takeda Pharmaceutical Company Limited (JP) 2008-04-16 EP disclosed
US-20070149570-A1 Piperidine derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-06-28 US disclosed
WO-2007015588-A1 PIPERIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149570-A1 Piperidine derivative and use thereof TACR1, OPRL1, TRPV1 PTGDR2 41/4885ERN1 4124/4885MAOA 760/4885
US-10968232-B2 Antidiabetic spirochroman compounds GPR119, GPR52, GPR55 PTGDR2 405/4885ERN1 2413/4885MAOA 4541/4885
US-20190337961-A1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS GPR119, GPR52, GPR55 PTGDR2 405/4885ERN1 2413/4885MAOA 4541/4885
US-20250223281-A1 ANTIDIABETIC COMPOUNDS AND COMPOSITIONS GPR119, GLP1R, GPR65 PTGDR2 370/4885ERN1 2622/4885MAOA 4332/4885
US-20110275515-A1 CYCLOPENTADIONE DERIVED HERBICIDES DDT, CYP1B1, CYP1A1 PTGDR2 1683/4885ERN1 4033/4885MAOA 1805/4885
US-20250073338-A1 CONJUGATE COMPOUNDS AND COMPOSITIONS GPR119, GPR65, GPR55 PTGDR2 261/4885ERN1 4163/4885MAOA 4007/4885
US-20250214951-A1 3-PHENYLISOXAZOLE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING EYE DISEASE, CONTAINING SAME AS ACTIVE INGREDIENT ATG7, BECN1, MAP1LC3B PTGDR2 258/4885ERN1 3296/4885MAOA 1043/4885
US-20240002354-A1 ANTIDIABETIC COMPOUNDS AND COMPOSITIONS GPR119, GLP1R, GPR65 PTGDR2 405/4885ERN1 2637/4885MAOA 4425/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.