Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 17/20 | 0.58 |
| ▸ | F13A1 | P00488 | 2/20 | 0.54 |
| ▸ | TGM1 | P22735 | 2/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | TGM6 | O95932 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2691897 | 0.86 | SIRT2 (0.67) | TGM2ITGB3CTSLCTSSSIRT2 | |
| SCHEMBL13598866 | 0.86 | ITGB3 (0.65) | TGM2F13A1TGM1ITGB3ITGA2B | |
| SCHEMBL6766563 | 0.86 | ITGB3 (0.65) | TGM2F13A1TGM1ITGB3ITGA2B | |
| SCHEMBL5712251 | 0.86 | ITGB3 (0.70) | TGM2F13A1TGM1ITGB3ITGA2B | |
| SCHEMBL209612 | 0.83 | SIRT2 (0.71) | TGM2ITGB3CTSLCTSSSIRT2 | |
| SCHEMBL14357907 | 0.82 | SIRT2 (0.72) | CTSLCTSSSIRT2SIRT1 | |
| SCHEMBL6769423 | 0.81 | TGM2 (0.60) | TGM2F13A1TGM1TGM6 | |
| SCHEMBL7294359 | 0.81 | DPP4 (0.58) | TGM2F13A1TGM1TGM6 | |
| SCHEMBL6860647 | 0.81 | TGM2 (0.69) | TGM2F13A1TGM1TGM6 | |
| SCHEMBL6860643 | 0.81 | TGM2 (0.69) | TGM2F13A1TGM1TGM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501807-A1 | SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093245-A1 | SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |