Water

Water

SCHEMBL6447238

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nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL28936266 1.00
SCHEMBL108163 0.91
Water SCHEMBL123474 0.83 CA1 (0.30)
Water SCHEMBL2322484 0.83
Water SCHEMBL11143526 0.83
Water SCHEMBL25317838 0.83
Water SCHEMBL7264010 0.83
Water SCHEMBL7133881 0.83
Water SCHEMBL16224274 0.83
Water SCHEMBL25316651 0.83

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6933339-B2 Nitrile rubber composition, vulcanizable nitrile rubber composition, and vulcanizate ZEON CORPORATION (JP) 2005-08-23 US claimed
US-20030166789-A1 Nitrile rubber composition, vulcanizable nitrile rubber composition, and vulcanizate ZEON CORPORATION (JP) 2003-09-04 US claimed
EP-1277796-A1 NITRILE RUBBER COMPOSITION, VULCANIZABLE NITRILE RUBBER COMPOSITION, AND VULCANIZATE Zeon Corporation (JP) 2003-01-22 EP claimed
WO-2025028232-A1 CROSSLINKABLE RUBBER COMPOSITION, CROSSLINKED RUBBER OBJECT, AND SEALING MATERIAL 日本ゼオン株式会社 2025-02-06 WO disclosed
EP-3816221-B1 CROSSLINKABLE NITRILE RUBBER COMPOSITION AND CROSSLINKED RUBBER MATERIAL ZEON CORP (JP) 2023-02-15 EP disclosed
US-11414499-B2 Crosslinkable nitrile rubber composition and crosslinked rubber material ZEON CORPORATION (JP) 2022-08-16 US disclosed
CN-112313274-B Crosslinkable nitrile rubber composition and crosslinked rubber 日本瑞翁株式会社 2022-08-12 CN disclosed
US-20210171671-A1 CROSSLINKABLE NITRILE RUBBER COMPOSITION AND CROSSLINKED RUBBER MATERIAL ZEON CORPORATION (JP) 2021-06-10 US disclosed
EP-3816221-A1 CROSSLINKABLE NITRILE RUBBER COMPOSITION AND CROSSLINKED RUBBER MATERIAL Zeon Corporation (JP) 2021-05-05 EP disclosed
CN-108350229-B Crosslinked rubber 日本瑞翁株式会社 2021-02-23 CN disclosed
CN-112313274-A Crosslinkable nitrile rubber composition and crosslinked rubber 日本瑞翁株式会社 2021-02-02 CN disclosed
US-10787525-B2 Rubber crosslinked material ZEON CORPORATION (JP) 2020-09-29 US disclosed
EP-3378891-B1 RUBBER CROSSLINKED MATERIAL ZEON CORP (JP) 2020-09-02 EP disclosed
US-20180327517-A1 RUBBER CROSSLINKED MATERIAL ZEON CORPORATION (JP) 2018-11-15 US disclosed
EP-3378891-A1 RUBBER CROSSLINKED MATERIAL Zeon Corporation (JP) 2018-09-26 EP disclosed
US-6933339-B2 Nitrile rubber composition, vulcanizable nitrile rubber composition, and vulcanizate ZEON CORPORATION (JP) 2005-08-23 US disclosed
US-20030166789-A1 Nitrile rubber composition, vulcanizable nitrile rubber composition, and vulcanizate ZEON CORPORATION (JP) 2003-09-04 US disclosed
EP-1277796-A1 NITRILE RUBBER COMPOSITION, VULCANIZABLE NITRILE RUBBER COMPOSITION, AND VULCANIZATE Zeon Corporation (JP) 2003-01-22 EP disclosed