Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.52 |
| ▸ | SLC19A1 | P41440 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TYMS | P04818 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447536 | 1.00 | DHFR (0.52) | DHFRSLC19A1KDM4EALOX15MAPT | |
| SCHEMBL14506393 | 0.90 | KDM4E (0.56) | DHFRSLC19A1KDM4EALOX15MAPT | |
| SCHEMBL824555 | 0.83 | ALOX15 (0.70) | KDM4EALOX15MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL29774638 | 0.83 | ALOX15 (0.70) | KDM4EALOX15MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6651469 | 0.81 | DHFR (0.54) | DHFRSLC19A1KDM4EALOX15MAPT | |
| SCHEMBL6651478 | 0.81 | DHFR (0.54) | DHFRSLC19A1KDM4EALOX15MAPT | |
| SCHEMBL27173134 | 0.80 | MEN1 (0.48) | DHFRSLC19A1KDM4EALOX15MAPT | |
| SCHEMBL23357901 | 0.79 | SDCBP (0.48) | DHFRSLC19A1KDM4EALOX15MAPT | |
| SCHEMBL22713348 | 0.79 | DHFR (0.44) | DHFRSLC19A1KDM4EALOX15MAPT | |
| SCHEMBL22713346 | 0.79 | DHFR (0.44) | DHFRSLC19A1KDM4EALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535034-B1 | PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS | WELLCOME FOUND (GB) | 2002-08-14 | — | — | EP | claimed |
| US-6855712-B2 | Combination of benzoquinazoline antifolates and protecting agents | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-15 | — | — | US | disclosed |
| US-6762188-B1 | INHIBITING THYMIDYLATE SYNTHASE; COLON, BREAST OR LUNG CARCINOMA | SMITHKLINE BEECHAM CORPORATION | 2004-07-13 | — | — | US | disclosed |
| EP-1199307-B1 | Pharmaceutically active benzoquinazoline compounds | WELLCOME FOUND (GB) | 2004-02-25 | — | — | EP | disclosed |
| US-20030203924-A1 | Novel combination of benzoquinazoline antifolates and protecting agents | SMITH GARY KEITH (US) | 2003-10-30 | — | — | US | disclosed |
| US-6579877-B2 | Reducing intestinal toxicity of a noncompetitive thymidylate synthase inhibitor by co-administering a folate derivative without blocking therapy; anticancer, antitumore agents | SMITHKLINE BEECHAM CORPORATION | 2003-06-17 | — | — | US | disclosed |
| US-20020137748-A1 | Novel combination of benzoquinazoline antifolates and protecting agents | SMITH GARY KEITH (US) | 2002-09-26 | — | — | US | disclosed |
| EP-0535034-B1 | PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS | WELLCOME FOUND (GB) | 2002-08-14 | — | — | EP | disclosed |
| EP-1199307-A1 | Pharmaceutically active benzoquinazoline compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 2002-04-24 | — | — | EP | disclosed |
| US-6358952-B1 | SIDE EFFECT REDUCTION WHEN ADMINISTERING NON-COMPETITIVE THYMIDYLATE SYNTHASE INHIBITOR AS ANTITUMOR AGENT | SMITHKLINE BEECHAM CORPORATION | 2002-03-19 | — | — | US | disclosed |
| US-6090941-A | Pharmaceutically active benzoquinazoline compounds | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0675719-B1 | NOVEL COMBINATION OF BENZOQUINAZOLINE ANTIFOLATES AND PROTECTING AGENTS | WELLCOME FOUND (GB) | 1998-06-10 | — | — | EP | disclosed |
| US-5663337-A | ENZYME, ANTITUMOR | GLAXO WELLCOME INC. (US) | 1997-09-02 | — | — | US | disclosed |
| US-5661155-A | THYMIDYLATE SYNTHASE INHIBITOR; ADMINISTERING TO THE MAMMAL SUFFERING FROM LEUKEMIA OR TUMOR 2-(5-(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLINE-9-YL) METHYL)AMINO)-1-OXO-2-ISOINDOLINYL)GLUTARIC ACID OR SALTS | GLAXO WELLCOME INC. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5405851-A | Administering benzoquinazoline thymidylate synthase inhibitors | BURROUGHS WELLCOME CO. (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0535034-A1 | PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1991019700-A1 | PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203924-A1 | Novel combination of benzoquinazoline antifolates and protecting agents | SLC19A1, DHFR, FOLR2 | DHFR 2/4885SLC19A1 1/4885KDM4E 3485/4885 |
| US-20020137748-A1 | Novel combination of benzoquinazoline antifolates and protecting agents | SLC19A1, DHFR, FOLR2 | DHFR 2/4885SLC19A1 1/4885KDM4E 3485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.