Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RNF4 | P78317 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | FABP7 | O15540 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL472178 | 0.91 | ALDH1A1 (0.38) | ALDH1A1TSHRLMNAELANEL3MBTL1 | |
| SCHEMBL20162506 | 0.91 | ALDH1A1 (0.38) | ALDH1A1TSHRLMNAELANEL3MBTL1 | |
| SCHEMBL20162498 | 0.89 | POLB (0.42) | RAB9ANPC1PPARGPPARAALDH1A1 | |
| SCHEMBL10003812 | 0.88 | CTSS (0.39) | RAB9ANPC1RNF4PPARGPPARA | |
| SCHEMBL10004648 | 0.85 | ALOX15 (0.39) | RAB9ANPC1RNF4ALDH1A1TSHR | |
| SCHEMBL20162507 | 0.84 | PPARG (0.38) | PPARGPPARAALDH1A1POLBELANE | |
| SCHEMBL4635211 | 0.84 | PPARG (0.38) | PPARGPPARAALDH1A1POLBELANE | |
| SCHEMBL10004534 | 0.83 | NPC1 (0.36) | RAB9ANPC1RNF4PPARGPPARA | |
| SCHEMBL29371149 | 0.81 | ALDH1A1 (0.40) | ALDH1A1TSHRLMNAELANEL3MBTL1 | |
| SCHEMBL29794309 | 0.81 | POLB (0.43) | RAB9ANPC1PPARGPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119779-B2 | Phosphoramidate derivatives | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED | 2012-02-21 | — | — | US | disclosed |
| EP-1709056-B1 | PHOSPHORAMIDATE DERIVATIVES | UNIV CARDIFF (GB) | 2009-06-17 | — | — | EP | disclosed |
| US-20070275910-A1 | Phosphoramidate Derivatives | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2007-11-29 | — | — | US | disclosed |
| EP-1709056-A1 | PHOSPHORAMIDATE DERIVATIVES | University College Cardiff Consultants Limited (GB) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070944-A1 | PHOSPHORAMIDATE DERIVATIVES | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275910-A1 | Phosphoramidate Derivatives | HRH4, HRH3, NR1H4 | RAB9A 4185/4885NPC1 3445/4885RNF4 2871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.