Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989990 | 0.88 | TNFRSF1A (0.72) | TNFRSF1ACYP1A2CYP2C19CES2CES1 | |
| SCHEMBL6989989 | 0.88 | TNFRSF1A (0.72) | TNFRSF1ACYP1A2CYP2C19CES2CES1 | |
| SCHEMBL28024599 | 0.82 | TNFRSF1A (0.64) | TNFRSF1ACYP1A2CYP2C19CES2CES1 | |
| SCHEMBL23137323 | 0.81 | ALDH1A1 (0.50) | TNFRSF1ACYP1A2CYP2C19MAPTMAOA | |
| SCHEMBL23137322 | 0.81 | ALDH1A1 (0.50) | TNFRSF1ACYP1A2CYP2C19MAPTMAOA | |
| SCHEMBL25191785 | 0.81 | TNFRSF1A (0.86) | TNFRSF1ACYP2C19MAPTMAOAMAOB | |
| SCHEMBL9798239 | 0.80 | TNFRSF1A (0.62) | TNFRSF1ACYP1A2CYP2C19CES2CES1 | |
| SCHEMBL956091 | 0.80 | CYP1A2 (0.63) | TNFRSF1ACYP1A2CYP2C19CES2CES1 | |
| SCHEMBL20273264 | 0.80 | TNFRSF1A (0.62) | TNFRSF1ACYP1A2CYP2C19CES2CES1 | |
| SCHEMBL6942827 | 0.80 | ALDH1A1 (0.67) | TNFRSF1ACYP1A2CYP2C19CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601678-A2 | FUSED PYRROLE COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2005-12-07 | — | — | EP | disclosed |
| US-20050014754-A1 | Fused pyrrole compounds | SYNTA PHARMACEUTICALS CORP. | 2005-01-20 | — | — | US | disclosed |
| WO-2004082606-A2 | FUSED PYRROLE COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2004-09-30 | — | — | WO | disclosed |
| US-5629332-A | FUNGICIDES | NIHON NOHYAKU CO., LTD. (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0679647-A1 | Novel antifungal triazole compound and production and use thereof | NIHON NOHYAKU CO., LTD. (JP) | 1995-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014754-A1 | Fused pyrrole compounds | PDE4A, PDE4B, IL4 | TNFRSF1A 42/4885CYP1A2 335/4885CYP2C19 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.