Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 7/20 | 0.39 |
| ▸ | JAK1 | P23458 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6456034 | 0.81 | TGFBR1 (0.41) | TGFBR1JAK3JAK2JAK1LMNA | |
| SCHEMBL6464368 | 0.79 | TGFBR1 (0.41) | TGFBR1JAK3JAK2JAK1 | |
| SCHEMBL6451777 | 0.78 | KMT2A (0.38) | TGFBR1JAK3JAK2JAK1LMNA | |
| SCHEMBL6456250 | 0.75 | KMT2A (0.39) | TGFBR1JAK3JAK2JAK1LMNA | |
| SCHEMBL6453841 | 0.73 | SLC6A2 (0.39) | LMNAMAPTKMT2ASMN1; SMN2S1PR1 | |
| SCHEMBL6455548 | 0.72 | CA2 (0.39) | KMT2AALDH1A1SMN1; SMN2S1PR1S1PR3 | |
| SCHEMBL7371438 | 0.71 | MEN1 (0.51) | NPSR1KMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL6454933 | 0.70 | TP53 (0.37) | TGFBR1LMNAPROKR1KMT2AMEN1 | |
| SCHEMBL6436419 | 0.68 | JAK3 (0.37) | TGFBR1JAK3JAK2LMNANPSR1 | |
| SCHEMBL6439078 | 0.67 | FAAH (0.36) | JAK3JAK2LMNANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-A2 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | claimed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | claimed |