Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 18/20 | 0.40 |
| ▸ | JAK2 | O60674 | 16/20 | 0.40 |
| ▸ | JAK1 | P23458 | 13/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6456034 | 0.81 | TGFBR1 (0.41) | TGFBR1JAK3JAK2JAK1 | |
| SCHEMBL6461886 | 0.81 | TGFBR1 (0.41) | TGFBR1JAK3JAK2JAK1 | |
| SCHEMBL6458237 | 0.79 | TGFBR1 (0.41) | TGFBR1JAK3JAK2JAK1 | |
| SCHEMBL6453841 | 0.78 | SLC6A2 (0.39) | — | |
| SCHEMBL6440581 | 0.73 | LMNA (0.41) | TGFBR1 | |
| SCHEMBL6450611 | 0.73 | SLC6A2 (0.40) | TGFBR1 | |
| SCHEMBL6454933 | 0.72 | TP53 (0.37) | TGFBR1 | |
| SCHEMBL6451777 | 0.70 | KMT2A (0.38) | TGFBR1JAK3JAK2JAK1 | |
| SCHEMBL6450409 | 0.70 | MAPK1 (0.40) | — | |
| SCHEMBL6456250 | 0.68 | KMT2A (0.39) | TGFBR1JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-A2 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |