Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.32 |
| ▸ | JAK3 | P52333 | 4/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6455548 | 0.82 | CA2 (0.39) | KMT2A | |
| SCHEMBL6458237 | 0.78 | TGFBR1 (0.41) | KMT2ATGFBR1KAT5JAK2JAK3 | |
| SCHEMBL6456250 | 0.73 | KMT2A (0.39) | KMT2AHDAC6TGFBR1JAK2JAK3 | |
| SCHEMBL6456034 | 0.72 | TGFBR1 (0.41) | TGFBR1JAK2JAK3JAK1LMNA | |
| SCHEMBL6453841 | 0.72 | SLC6A2 (0.39) | KMT2ALMNA | |
| SCHEMBL6464368 | 0.70 | TGFBR1 (0.41) | TGFBR1JAK2JAK3JAK1 | |
| SCHEMBL6461886 | 0.70 | TGFBR1 (0.41) | KMT2ATGFBR1JAK2JAK3JAK1 | |
| SCHEMBL6454933 | 0.68 | TP53 (0.37) | KMT2ATGFBR1TP53LMNA | |
| SCHEMBL6436408 | 0.67 | JAK3 (0.37) | HDAC6TGFBR1JAK2JAK3JAK1 | |
| SCHEMBL6436419 | 0.66 | JAK3 (0.37) | TGFBR1JAK2JAK3LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-A2 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |