Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1538024 | 0.74 | HTR6 (0.53) | HTR6MAPTKMT2AALDH1A1 | |
| SCHEMBL7994183 | 0.69 | HTR6 (0.52) | HTR6HTR1ADRD2TERTNPC1 | |
| SCHEMBL7591875 | 0.67 | HTR6 (0.50) | HTR6HTR1ADRD2TERTMAPT | |
| SCHEMBL7034964 | 0.67 | GAA (0.42) | HTR6NPC1TP53MAPTNFKB1 | |
| SCHEMBL4848922 | 0.65 | CYP2A6 (0.53) | HTR6MAPTKMT2AALDH1A1 | |
| Hexane SCHEMBL28857999 | 0.65 | DRD2 (0.56) | DRD2NPC1TP53MAPTNFKB1 | |
| SCHEMBL24220554 | 0.64 | KCNH2 (0.53) | DRD2KMT2A | |
| SCHEMBL31743075 | 0.64 | ALDH1A1 (0.49) | HTR6HTR1ADRD2TERTMAPT | |
| Hexadecane SCHEMBL28172309 | 0.64 | DRD2 (0.55) | DRD2NPC1TP53MAPTNFKB1 | |
| SCHEMBL6437205 | 0.64 | HTR6 (0.61) | HTR6HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897215-B1 | Compounds having 5-HT6 receptor antagonist activity | NPS ALLELIX CORP. (CA) | 2005-05-24 | — | — | US | disclosed |
| WO-2001032660-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR ANTAGONIST ACTIVITY | NPS ALLELIX CORP. (US) | 2001-05-10 | — | — | WO | disclosed |