Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9347312 | 1.00 | TMEM97 (0.41) | TMEM97SIGMAR1LMNAHCRTR2LTA4H | |
| SCHEMBL6987664 | 0.86 | SIGMAR1 (0.39) | TMEM97SIGMAR1HCRTR2HCRTR1TSHR | |
| SCHEMBL1409902 | 0.86 | TMEM97 (0.37) | TMEM97SIGMAR1HCRTR2LTA4HHCRTR1 | |
| SCHEMBL13528036 | 0.79 | SIGMAR1 (0.41) | TMEM97SIGMAR1HCRTR2LTA4HHCRTR1 | |
| SCHEMBL13528035 | 0.79 | SIGMAR1 (0.41) | TMEM97SIGMAR1HCRTR2LTA4HHCRTR1 | |
| SCHEMBL13528037 | 0.79 | SIGMAR1 (0.41) | TMEM97SIGMAR1HCRTR2LTA4HHCRTR1 | |
| SCHEMBL31335170 | 0.79 | SIGMAR1 (0.41) | TMEM97SIGMAR1HCRTR2LTA4HHCRTR1 | |
| SCHEMBL21210139 | 0.79 | SIGMAR1 (0.41) | TMEM97SIGMAR1HCRTR2LTA4HHCRTR1 | |
| SCHEMBL21210136 | 0.79 | SIGMAR1 (0.41) | TMEM97SIGMAR1HCRTR2LTA4HHCRTR1 | |
| SCHEMBL6988972 | 0.74 | SIGMAR1 (0.38) | TMEM97SIGMAR1HCRTR2HCRTR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165319-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-28 | — | — | US | disclosed |
| US-8119631-B2 | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-21 | — | — | US | disclosed |
| US-20050143436-A1 | Inhibitors of interleukin-1beta converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165319-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | IL1A, IFNAR1, IL1B | TMEM97 4247/4885SIGMAR1 2980/4885LMNA 485/4885 |
| US-20050143436-A1 | Inhibitors of interleukin-1beta converting enzyme | IL1A, IL1B, IFNAR1 | TMEM97 4407/4885SIGMAR1 3087/4885LMNA 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.