Sugi Predict

Sugi Predict / Compounds / SCHEMBL6461970

SCHEMBL6461970

SCHEMBL6461970

NC(=O)C(c1ccccn1)c1c(Cl)cc(N)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 2/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ S1PR2 O95136 1/20 0.40
▸ S1PR4 O95977 1/20 0.40
▸ S1PR3 Q99500 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.36
▸ CYP3A4 P08684 1/20 0.36
▸ NPY2R P49146 2/20 0.36
▸ TRPV3 Q8NET8 1/20 0.36
▸ GRM4 Q14833 2/20 0.35
▸ NPC1 O15118 4/20 0.35
▸ RAB9A P51151 4/20 0.35
▸ SMN1; SMN2 Q16637 3/20 0.35
▸ LMNA P02545 2/20 0.35
▸ MAPT P10636 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ PKM P14618 2/20 0.35
▸ MITF O75030 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15718166 0.76 ALDH1A1 (0.49) CYP1A2ALDH1A1KDM4ENPSR1CYP3A4
SCHEMBL30473858 0.76 ALDH1A1 (0.49) CYP1A2ALDH1A1KDM4ENPSR1CYP3A4
SCHEMBL2134676 0.75 ALDH1A1 (0.47) CYP1A2ALDH1A1S1PR2S1PR4S1PR3
SCHEMBL639563 0.74 ALDH1A1 (0.64) CYP1A2ALDH1A1S1PR2S1PR4S1PR3
SCHEMBL7759530 0.74 ALDH1A1 (0.64) CYP1A2ALDH1A1S1PR2S1PR4S1PR3
Hydrochloric Acid SCHEMBL4200885 0.73 ALDH1A1 (0.62) CYP1A2ALDH1A1S1PR2S1PR4S1PR3
Hydrochloric Acid SCHEMBL27529639 0.73 ALDH1A1 (0.62) CYP1A2ALDH1A1S1PR2S1PR4S1PR3
SCHEMBL6465831 0.72 MAPT (0.46) ALDH1A1S1PR2S1PR4S1PR3NPSR1
SCHEMBL438354 0.71 CYP1A2 (0.47) CYP1A2ALDH1A1KDM4ENPSR1CYP3A4
SCHEMBL23042521 0.71 CYP1A2 (0.44) CYP1A2ALDH1A1S1PR2S1PR4S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6894046-B2 IL-5 inhibiting 6-azauracil derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2005-05-17 — — US disclosed
EP-1114046-B1 INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2003-04-23 — — EP disclosed
US-20020010177-A1 IL-5 inhibiting 6-azauracil derivatives JANSSEN CILAG S.A. (FR) 2002-01-24 — — US disclosed
EP-1114046-A1 INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES Janssen Pharmaceutica N.V. (BE) 2001-07-11 — — EP disclosed
WO-2000017195-A1 INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2000-03-30 — — WO disclosed
EP-0987265-A1 Interleukin-5 inhibiting 6-azauracil derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2000-03-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020010177-A1 IL-5 inhibiting 6-azauracil derivatives ALOX5, IL5, IL6ST CYP1A2 1140/4885ALDH1A1 1746/4885S1PR2 689/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.