SCHEMBL646209

SCHEMBL646209

COc1ccc(C=C(C(=O)O)C(C)CC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C)cc1OC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CYP1A2 P05177 1/20 0.43
KDM4E B2RXH2 3/20 0.42
HTT P42858 2/20 0.42
ALDH1A1 P00352 6/20 0.41
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
MAPK1 P28482 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HSD17B10 Q99714 1/20 0.41
AKR1C3 P42330 1/20 0.41
NFE2L2 Q16236 1/20 0.40
AKR1C2 P52895 1/20 0.40
TAS1R3 Q7RTX0 1/20 0.39
TAS1R1 Q7RTX1 1/20 0.39
PKM P14618 1/20 0.39
TTR P02766 1/20 0.38
TSHR P16473 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9119870 0.79 ALDH1A1 (0.41) GAATDP1CYP1A2KDM4EHTT
SCHEMBL9440652 0.78 MEN1 (0.40) GAATDP1CYP1A2KDM4EHTT
SCHEMBL25329704 0.76 NFE2L2 (0.50) CYP1A2KDM4EHTTALDH1A1HPGD
SCHEMBL29579523 0.76 NFE2L2 (0.50) CYP1A2KDM4EHTTALDH1A1HPGD
SCHEMBL646207 0.76 NFE2L2 (0.50) CYP1A2KDM4EHTTALDH1A1HPGD
SCHEMBL16160025 0.69 GAA (0.67) GAATDP1CYP1A2KDM4EHTT
SCHEMBL7813363 0.68 GAA (0.75) GAATDP1CYP1A2KDM4EHTT
SCHEMBL2225902 0.68 GAA (0.75) GAATDP1CYP1A2KDM4EHTT
SCHEMBL23761193 0.68 GAA (0.65) GAATDP1CYP1A2KDM4EHTT
SCHEMBL7813366 0.68 GAA (0.75) GAATDP1CYP1A2KDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12383476-B2 W/O/W emulsion composition SHISEIDO COMPANY, LTD. (JP) 2025-08-12 US disclosed
WO-2024142969-A1 WATER-IN-OIL EMULSION COMPOSITION 株式会社 資生堂 2024-07-04 WO disclosed
WO-2024080367-A1 POLYSILOXANE-COATED METAL OXIDE PARTICLES, DISPERSION LIQUID, COMPOSITION, COSMETIC, AND METHOD FOR PRODUCING POLYSILOXANE-COATED METAL OXIDE PARTICLES 住友大阪セメント株式会社 2024-04-18 WO disclosed
US-20220362112-A1 W/O/W EMULSION COMPOSITION SHISEIDO COMPANY, LTD. (JP) 2022-11-17 US disclosed
US-20180161255-A1 SILICON OXIDE-COATED ZINC OXIDE, COMPOSITION CONTAINING SILICON OXIDE-COATED ZINC OXIDE, AND COSMETIC PRODUCT SUMITOMO OSAKA CEMENT CO., LTD. (JP) 2018-06-14 US disclosed
US-8119108-B2 Dispersion of microparticulate titanium oxide and cosmetics containing the same SHISEIDO CO., LTD. (JP) 2012-02-21 US disclosed
US-20090169496-A1 Dispersion Of Microparticulate Titanium Oxide And Cosmetics Containing The Same SHISEIDO CO., LTD. (JP) 2009-07-02 US disclosed
EP-1974717-A1 DISPERSION OF FINE TITANIUM OXIDE PARTICLES AND COSMETIC PREPARATION CONTAINING THE SAME Shiseido Company, Limited (JP) 2008-10-01 EP disclosed
US-5315022-A Sunscreen SHISEIDO COMPANY LTD. (JP) 1994-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090169496-A1 Dispersion Of Microparticulate Titanium Oxide And Cosmetics Containing The Same THPO, TPSD1, TPSG1 GAA 159/4885TDP1 2195/4885CYP1A2 1364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.