SCHEMBL646207

SCHEMBL646207

COc1ccc(C=CC(=O)OC(C)CC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C)cc1OC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.50
TTR P02766 1/20 0.48
FDPS P14324 2/20 0.48
KDM4E B2RXH2 5/20 0.48
ALDH1A1 P00352 4/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
HPGD P15428 1/20 0.48
ALOX15 P16050 1/20 0.48
MAPK1 P28482 1/20 0.48
HSD17B10 Q99714 1/20 0.48
MAPT P10636 2/20 0.48
HDAC1 Q13547 2/20 0.47
HDAC2 Q92769 2/20 0.47
HDAC8 Q9BY41 2/20 0.47
GLA P06280 1/20 0.46
HTT P42858 1/20 0.46
RECQL P46063 1/20 0.46
KMT2A Q03164 3/20 0.46
ABCG2 Q9UNQ0 2/20 0.46
MEN1 O00255 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29579523 1.00 NFE2L2 (0.50) NFE2L2TTRFDPSKDM4EALDH1A1
SCHEMBL25329704 1.00 NFE2L2 (0.50) NFE2L2TTRFDPSKDM4EALDH1A1
SCHEMBL9119856 0.91 NFE2L2 (0.50) NFE2L2TTRFDPSKDM4EALDH1A1
2,4-Dihydroxybenzophenone SCHEMBL23174978 0.85 ALDH1A1 (0.48) TTRKDM4EALDH1A1SMN1; SMN2HPGD
SCHEMBL647362 0.79 ALDH1A1 (0.47) KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10
SCHEMBL646209 0.76 GAA (0.44) NFE2L2TTRKDM4EALDH1A1SMN1; SMN2
SCHEMBL730348 0.75 KDM4E (0.66) NFE2L2TTRFDPSKDM4EALDH1A1
Methyl Cis-3,4-Dimethoxycinnamate SCHEMBL2411956 0.71 FDPS (0.80) NFE2L2TTRFDPSKDM4EALDH1A1
Methyl Cis-3,4-Dimethoxycinnamate SCHEMBL2411955 0.71 FDPS (0.80) NFE2L2TTRFDPSKDM4EALDH1A1
SCHEMBL890347 0.71 KDM4E (0.56) NFE2L2TTRFDPSKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12383476-B2 W/O/W emulsion composition SHISEIDO COMPANY, LTD. (JP) 2025-08-12 US disclosed
WO-2024142969-A1 WATER-IN-OIL EMULSION COMPOSITION 株式会社 資生堂 2024-07-04 WO disclosed
US-20240139085-A1 SURFACE-MODIFIED ZINC OXIDE PARTICLES, DISPERSION LIQUID, COSMETIC PREPARATION, AND METHOD FOR PRODUCING SURFACE-MODIFIED ZINC OXIDE PARTICLES SUMITOMO OSAKA CEMENT CO., LTD. (JP) 2024-05-02 US disclosed
WO-2024080367-A1 POLYSILOXANE-COATED METAL OXIDE PARTICLES, DISPERSION LIQUID, COMPOSITION, COSMETIC, AND METHOD FOR PRODUCING POLYSILOXANE-COATED METAL OXIDE PARTICLES 住友大阪セメント株式会社 2024-04-18 WO disclosed
EP-4296232-A1 SURFACE-MODIFIED ZINC OXIDE PAPRTICLES, DISPERSION LIQUID, COSMETIC PREPARATION, AND METHOD FOR PRODUCING SURFACE-MODIFIED ZINC OXIDE PARTICLES Sumitomo Osaka Cement Co., Ltd. (JP) 2023-12-27 EP disclosed
WO-2023210618-A1 SURFACE-TREATED ZINC OXIDE PARTICLES, DISPERSION LIQUID, COSMETIC MATERIAL, METHOD FOR PRODUCING SURFACE-TREATED ZINC OXIDE PARTICLES 住友大阪セメント株式会社 2023-11-02 WO disclosed
WO-2023190487-A1 SURFACE-MODIFIED ZINC OXIDE PARTICLES, DISPERSION LIQUID AND COSMETIC PREPARATION 住友大阪セメント株式会社 2023-10-05 WO disclosed
EP-4253322-A1 ZINC OXIDE POWDER, LIQUID DISPERSION, COATING MATERIAL, AND COSMETIC Sumitomo Osaka Cement Co., Ltd. (JP) 2023-10-04 EP disclosed
EP-4253323-A1 ZINC OXIDE POWDER, DISPERSION LIQUID, COATING MATERIAL, AND COSMETIC Sumitomo Osaka Cement Co., Ltd. (JP) 2023-10-04 EP disclosed
US-20230263708-A1 SURFACE-MODIFIED ZINC OXIDE PARTICLES, DISPERSION SOLUTION, AND COSMETIC SUMITOMO OSAKA CEMENT CO., LTD. (JP) 2023-08-24 US disclosed
US-9403691-B1 Zinc oxide powder, dispersion, paint, and cosmetic material SUMITOMO OSAKA CEMENT CO., LTD. (JP) 2016-08-02 US disclosed
US-8119108-B2 Dispersion of microparticulate titanium oxide and cosmetics containing the same SHISEIDO CO., LTD. (JP) 2012-02-21 US disclosed
US-20090169496-A1 Dispersion Of Microparticulate Titanium Oxide And Cosmetics Containing The Same SHISEIDO CO., LTD. (JP) 2009-07-02 US disclosed
EP-1974717-A1 DISPERSION OF FINE TITANIUM OXIDE PARTICLES AND COSMETIC PREPARATION CONTAINING THE SAME Shiseido Company, Limited (JP) 2008-10-01 EP disclosed
US-20040137019-A1 Cosmetic w/o/w emulsion preparation SHISEIDO COMPANY, LTD. (JP) 2004-07-15 US disclosed
EP-1369101-A1 COSMETIC W/O/W EMULSION PREPARATION SHISEIDO COMPANY LIMITED (JP) 2003-12-10 EP disclosed
EP-0350314-B1 Silicone type cinnamic acid derivative, preparation method thereof, uv-ray absorber, and external skin treatment agent. SHISEIDO CO LTD (JP) 1995-12-13 EP disclosed
US-5315022-A Sunscreen SHISEIDO COMPANY LTD. (JP) 1994-05-24 US disclosed
US-5093511-A SILICONE TYPE CINNAMIC ACID DERIVATIVE, PREPARATION METHOD THEREOF, UV-RAY ABSORBER, AND EXTERNAL SKIN TREATMENT AGENT SHISEIDO COMPANY, LTD. (JP) 1992-03-03 US disclosed
EP-0350314-A2 Silicone type cinnamic acid derivative, preparation method thereof, uv-ray absorber, and external skin treatment agent. SHISEIDO COMPANY LIMITED (JP) 1990-01-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090169496-A1 Dispersion Of Microparticulate Titanium Oxide And Cosmetics Containing The Same THPO, TPSD1, TPSG1 NFE2L2 2321/4885TTR 1945/4885FDPS 2785/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.