SCHEMBL646273

SCHEMBL646273

COc1ccc2c3c([nH]c2c1)C(C)NCC3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 1.00
KDM4E B2RXH2 2/20 1.00
POLB P06746 2/20 1.00
GAA P10253 2/20 1.00
PSMD14 O00487 1/20 1.00
HTR2B P41595 6/20 0.80
ALDH1A1 P00352 2/20 0.80
HTR7 P34969 7/20 0.56
ADRA2A P08913 1/20 0.56
ADRA2B P18089 1/20 0.56
ADRA2C P18825 1/20 0.56
NISCH Q9Y2I1 1/20 0.56
ACHE P22303 2/20 0.54
MAPKAPK2 P49137 3/20 0.54
MAPKAPK5 Q8IW41 1/20 0.54
HTR2C P28335 9/20 0.51
HTR2A P28223 8/20 0.51
CHRM4 P08173 2/20 0.50
DRD2 P14416 2/20 0.50
HTR6 P50406 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22800099 1.00 MAPT (1.00) MAPTKDM4EPOLBGAAPSMD14
Hydrochloric Acid SCHEMBL31289351 0.99 MAPT (0.97) MAPTKDM4EPOLBGAAPSMD14
Hydrochloric Acid SCHEMBL31289353 0.99 MAPT (0.97) MAPTKDM4EPOLBGAAPSMD14
SCHEMBL31289358 0.97 MAPT (0.95) MAPTKDM4EPOLBGAAPSMD14
Adrenoglomerulotropin SCHEMBL356345 0.89 HTR2B (1.00) MAPTKDM4EPOLBGAAPSMD14
SCHEMBL763727 0.82 HTR7 (0.72) MAPTKDM4EPOLBGAAPSMD14
SCHEMBL15236165 0.81 MAPT (0.68) MAPTKDM4EPOLBGAAPSMD14
SCHEMBL6239907 0.81 MAPKAPK2 (0.82) MAPTKDM4EPOLBGAAPSMD14
SCHEMBL8321957 0.80 MAPT (0.67) MAPTKDM4EPOLBGAAPSMD14
SCHEMBL12067592 0.80 HTR2B (0.67) MAPTKDM4EPOLBGAAPSMD14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 483 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137652-A1 Composition Comprising Non-Phosphorylated Tryptamine SINTALICA S R L (IT) 2026-05-21 US claimed
US-20250339403-A1 Tryptamine Formulations and Uses Thereof Natural MedTech Pty Ltd (AU) 2025-11-06 US claimed
EP-4638419-A1 NON-HALLUCINOGENIC TRYPTAMINE COMPOUNDS, PREPARATION, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Sintalica S.r.l. (IT) 2025-10-29 EP claimed
EP-4618981-A1 COMBINATIONS OF MONOAMINE OXIDASE INHIBITORS AND SEROTONIN RECEPTOR AGONISTS AND THEIR THERAPEUTIC USE Remedi, Inc. (US) 2025-09-24 EP claimed
EP-4615444-A1 TRYPTAMINE FORMULATIONS AND USES THEREOF Natural Medtech Pty Ltd (AU) 2025-09-17 EP claimed
US-20250281399-A1 A MUCOADHESIVE FILM COMPRISING A PHARMACEUTICALLY ACTIVE AGENT AND USES THEREOF SHORT WAVE PHARMA INC. (CA) 2025-09-11 US claimed
EP-4601655-A1 DELIVERY SYSTEM FOR THE CONTROLLED RELEASE OF PSYCHEDELIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USES THEREOF Sintalica S.r.l. (IT) 2025-08-20 EP claimed
EP-4601665-A1 COMPOSITION COMPRISING TRYPTAMINES AND MAOIS COMPOUNDS SELECTED FROM ?-CARBOLINE INHIBITORS, AND PHARMACEUTICAL USES THEREOF Sintalica S.r.l. (IT) 2025-08-20 EP claimed
EP-4601627-A1 COMPOSITION COMPRISING NOT PHOSPHORYLATED TRYPTAMINE, ANTIOXIDANTS, AND SUPPLEMENTS, AND PHARMACEUTICAL USES THEREOF Sintalica S.r.l. (IT) 2025-08-20 EP claimed
EP-4518855-A1 A MUCOADHESIVE FILM COMPRISING A PHARMACEUTICALLY ACTIVE AGENT AND USES THEREOF Short Wave Pharma Inc. (CA) 2025-03-12 EP claimed
CN-102791134-A Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions PERKINELMER INC 2012-11-21 CN claimed
EP-2506717-A1 METHOD OF USING DOPAMINE REUPTAKE INHIBITORS AND THEIR ANALOGS FOR TREATING DIABETES SYMPTOMS AND DELAYING OR PREVENTING DIABETES-ASSOCIATED PATHOLOGIC CONDITIONS PerkinElmer, Inc. (US) 2012-10-10 EP claimed
WO-2011069051-A1 METHOD OF USING DOPAMINE REUPTAKE INHIBITORS AND THEIR ANALOGS FOR TREATING DIABETES SYMPTOMS AND DELAYING OR PREVENTING DIABETES-ASSOCIATED PATHOLOGIC CONDITIONS CALIPER LIFE SCIENCES, INC. (US) 2011-06-09 WO claimed
US-20090104196-A1 Antibodies For Use in Identifying and/or Scoring Prostate Cancer and Androgen Receptor-Dependent Gene Expression Control UNIVERSITAETSKLINIKUM FREIBURG (DE) 2009-04-23 US claimed
US-20080139665-A1 Androgen Receptor-Dependent Gene Expression Control UNIVERSITAETSKLINIKUM FREIBURG (DE) 2008-06-12 US claimed
WO-2007006581-A2 TARGETING LSD1 FOR USE IN IDENTIFYING AND/OR SCORING PROSTATE CANCER AND FOR CONTROLLING ANROGEN RECEPTOR-DEPENDENT GENE EXPRESSION Universitätsklinikum Freiburg (DE) 2007-01-18 WO claimed
EP-1704859-A1 Androgen receptor-dependent gene expression control by inhibiting the amine oxidase activity of lysine-specific demethylase (LSD1) Universitätsklinikum Freiburg (DE) 2006-09-27 EP claimed
WO-2006087206-A2 ANDROGEN RECEPTOR-DEPENDENT GENE EXPRESSION CONTROL BY INHIBITING THE AMINE OXIDASE ACTIVITY OF LYSINE-SPECIFIC DEMETHYLASE (LSD1) Universitätsklinikum Freiburg (DE) 2006-08-24 WO claimed
EP-1693062-A2 Androgen receptor-dependent gene expression control Universitätsklinikum Freiburg (DE) 2006-08-23 EP claimed
US-5591738-A Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof NDA INTERNATIONAL, INC. (US) 1997-01-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250281399-A1 A MUCOADHESIVE FILM COMPRISING A PHARMACEUTICALLY ACTIVE AGENT AND USES THEREOF MUC1, CFTR, LIPA MAPT 1012/4885KDM4E 4859/4885POLB 2204/4885
US-20260137652-A1 Composition Comprising Non-Phosphorylated Tryptamine HTR2B, BDNF, HTR3B MAPT 705/4885KDM4E 4470/4885POLB 1077/4885
US-20250339403-A1 Tryptamine Formulations and Uses Thereof MAOA, MAOB, TPH1 MAPT 801/4885KDM4E 1199/4885POLB 3450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.