Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6464717 | 1.00 | PDE4A (0.47) | PDE4APDK1ALDH1A1MEN1KMT2A | |
| SCHEMBL16954759 | 0.84 | TTR (0.50) | PDE4APDK1ALDH1A1MEN1KMT2A | |
| SCHEMBL11682060 | 0.83 | XDH (0.52) | PDK1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2976612 | 0.81 | GAA (0.60) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL7984258 | 0.81 | GAA (0.45) | ALDH1A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL2976618 | 0.81 | GAA (0.60) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL1865824 | 0.80 | CASP6 (0.55) | ALDH1A1MEN1KMT2APOLBGAA | |
| SCHEMBL6990630 | 0.79 | LMNA (0.58) | ALDH1A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9521629 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL16098843 | 0.78 | CASP6 (0.63) | PDK1MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601675-A1 | PURIN-6-ONE-DERIVATIVES | ALTANA Pharma AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004089953-A1 | PURIN-6-ONE-DERIVATIVES | ALTANA PHARMA AG (DE) | 2004-10-21 | — | — | WO | disclosed |