Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1946059 | 0.83 | ALDH1A1 (0.51) | HPGDALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL1946617 | 0.74 | HPGD (0.59) | HPGDALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL7443806 | 0.72 | G6PD (0.53) | HPGDALDH1A1KDM4ESMN1; SMN2CYP3A4 | |
| SCHEMBL7443811 | 0.72 | G6PD (0.53) | HPGDALDH1A1KDM4ESMN1; SMN2CYP3A4 | |
| SCHEMBL2337883 | 0.70 | HPGD (0.58) | HPGDALDH1A1KDM4ESMN1; SMN2CYP3A4 | |
| SCHEMBL1945517 | 0.69 | ALDH1A1 (0.57) | HPGDALDH1A1KDM4ESMN1; SMN2CYP3A4 | |
| SCHEMBL6982894 | 0.69 | HPGD (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL30877025 | 0.69 | HPGD (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL7836791 | 0.69 | HPGD (0.57) | HPGDALDH1A1KDM4ESMN1; SMN2CYP3A4 | |
| SCHEMBL1946628 | 0.69 | KMT2A (0.54) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515972-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003106459-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-24 | — | — | WO | disclosed |