Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 1/20 | 0.53 |
| ▸ | LIG1 | P18858 | 1/20 | 0.51 |
| ▸ | LIG3 | P49916 | 1/20 | 0.51 |
| ▸ | LIG4 | P49917 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443811 | 1.00 | G6PD (0.53) | G6PDLIG1LIG3LIG4HPGD | |
| SCHEMBL1946059 | 0.85 | ALDH1A1 (0.51) | HPGDKDM4EALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL4407466 | 0.80 | G6PD (0.57) | G6PDLIG1LIG3LIG4HPGD | |
| SCHEMBL7436514 | 0.80 | G6PD (0.57) | G6PDLIG1LIG3LIG4HPGD | |
| SCHEMBL1945517 | 0.75 | ALDH1A1 (0.57) | HPGDKDM4EALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL28178755 | 0.72 | ALDH1A1 (0.53) | HPGDKDM4EALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL6464993 | 0.72 | HPGD (0.53) | HPGDKDM4EALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL1946628 | 0.71 | KMT2A (0.54) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL22105776 | 0.71 | G6PD (0.53) | G6PDLIG1LIG3LIG4HPGD | |
| SCHEMBL1946195 | 0.70 | PKM (0.47) | HPGDALDH1A1CYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |