SCHEMBL6465689

SCHEMBL6465689

COc1ccc(CS(=O)(=O)NC(=O)Nc2ccccc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.63
NPC1 O15118 4/20 0.63
FPR2 P25090 2/20 0.60
HIF1A Q16665 1/20 0.60
MET P08581 2/20 0.56
SAE1 Q9UBE0 1/20 0.55
UBA2 Q9UBT2 1/20 0.55
KDM4E B2RXH2 1/20 0.55
POLB P06746 1/20 0.55
SMN1; SMN2 Q16637 3/20 0.51
ALDH1A1 P00352 2/20 0.51
GAA P10253 1/20 0.51
HTT P42858 1/20 0.51
MAPT P10636 1/20 0.51
LMNA P02545 1/20 0.51
TP53 P04637 1/20 0.51
KLK7 P49862 1/20 0.51
EGFR P00533 1/20 0.50
ERBB2 P04626 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6466509 0.95 MET (0.61) RAB9ANPC1FPR2HIF1AMET
SCHEMBL6466493 0.89 SAE1 (0.71) RAB9ANPC1FPR2HIF1AMET
SCHEMBL6464498 0.85 ACP1 (0.61) METKDM4ESMN1; SMN2LMNATP53
SCHEMBL6468349 0.83 PGR (0.62) METSMN1; SMN2LMNATP53
SCHEMBL3296646 0.83 NPC1 (0.61) RAB9ANPC1KDM4EPOLBALDH1A1
SCHEMBL6463105 0.80 CA1 (0.57) METSAE1UBA2
SCHEMBL23747417 0.79 NPC1 (0.71) RAB9ANPC1HIF1ASMN1; SMN2HTT
SCHEMBL7777663 0.79 LMNA (0.71) RAB9ANPC1POLBSMN1; SMN2ALDH1A1
SCHEMBL6467730 0.79 ACP1 (0.51) RAB9ANPC1METALDH1A1GAA
SCHEMBL15376420 0.78 SMN1; SMN2 (0.53) SMN1; SMN2HTTEGFRERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5449657-A Sulfonyl (thio)ureas NEW OJI PAPER CO., LTD. (JP) 1995-09-12 US claimed
EP-0615859-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-09-21 EP claimed
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
US-20050106491-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-05-19 US disclosed
EP-1480835-A1 HEAT SENSITIVE RECORDING MATERIAL Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
EP-1480836-A1 MIXTURE OF COLOUR DEVELOPERS Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
US-6740465-B2 MULTILAYER; TRANSPARENT SUPPORT; HEAT SENSITIVE ELEMENT AND RELEASE AGENT SIPIX IMAGING, INC. 2004-05-25 US disclosed
WO-2003074284-A1 MIXTURE OF COLOUR DEVELOPERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
WO-2003074285-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
EP-1289768-A2 IMAGING MEDIA CONTAINING HEAT DEVELOPABLE PHOTOSENSITIVE MICROCAPSULES Sipix Imaging, Inc. (US) 2003-03-12 EP disclosed
US-20020155372-A1 Imaging media containing heat developable photosensitive microcapsules SIPIX IMAGING, INC. 2002-10-24 US disclosed
WO-2001092024-A2 IMAGING MEDIA CONTAINING HEAT DEVELOPABLE PHOTOSENSITIVE MICROCAPSULES SIPIX IMAGING, INC. (US) 2001-12-06 WO disclosed
US-5449657-A Sulfonyl (thio)ureas NEW OJI PAPER CO., LTD. (JP) 1995-09-12 US disclosed
EP-0615859-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-09-21 EP disclosed