Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467037 | 0.91 | FAAH (0.36) | LMNAMAPTKMT2AMEN1TSHR | |
| SCHEMBL7049043 | 0.90 | MAPT (0.38) | LMNAMAPTHTTSMN1; SMN2MAPK1 | |
| SCHEMBL7045361 | 0.83 | ATM (0.37) | MAPTXDHMAPK1 | |
| SCHEMBL7049306 | 0.82 | DAGLA (0.44) | LMNAMAPTKMT2AMEN1TSHR | |
| SCHEMBL6062665 | 0.79 | MTNR1A (0.35) | LMNAMAPTKMT2AMEN1TSHR | |
| Hydrochloric Acid SCHEMBL6465937 | 0.79 | FAAH (0.35) | LMNAMAPTKMT2AMEN1TSHR | |
| SCHEMBL6464160 | 0.78 | LMNA (0.39) | LMNAMAPTKMT2AMEN1TSHR | |
| SCHEMBL6467736 | 0.78 | ALDH1A1 (0.36) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL7044868 | 0.77 | LMNA (0.37) | LMNAMAPTKMT2AMEN1TSHR | |
| SCHEMBL6462741 | 0.76 | FAAH (0.36) | LMNAMAPTKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |