Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 10/20 | 0.39 |
| ▸ | FAAH | O00519 | 8/20 | 0.39 |
| ▸ | CES1 | P23141 | 5/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | BMP1 | P13497 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049335 | 0.74 | DAGLA (0.42) | DAGLAFAAHCES1XDHMMP2 | |
| SCHEMBL6463072 | 0.74 | DAGLA (0.60) | DAGLAFAAHCES1XDH | |
| SCHEMBL6467342 | 0.73 | DAGLA (0.41) | DAGLAFAAHCES1XDHMMP2 | |
| SCHEMBL6466348 | 0.70 | FAAH (0.43) | DAGLAFAAHCES1MMP2 | |
| SCHEMBL7048552 | 0.68 | CTSS (0.39) | DAGLAFAAHCES1MMP2 | |
| Hydrochloric Acid SCHEMBL7114461 | 0.67 | CTSS (0.44) | DAGLAFAAHCES1MMP2 | |
| SCHEMBL6063084 | 0.67 | CTSS (0.53) | DAGLAFAAHCES1MMP2 | |
| SCHEMBL7049760 | 0.67 | DAGLA (0.54) | DAGLAFAAHCES1XDHPPARG | |
| SCHEMBL6467552 | 0.67 | DAGLA (0.51) | DAGLAFAAHCES1XDHPPARG | |
| SCHEMBL7047588 | 0.66 | FAAH (0.39) | DAGLAFAAHCES1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |
| EP-1161422-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055144-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |