SCHEMBL6467547

SCHEMBL6467547

CC(C)S(=O)(=O)NC(=O)Nc1ccc(Cl)c2ccccc12

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 8/20 0.43
IDO1 P14902 2/20 0.43
TRPV1 Q8NER1 1/20 0.40
KMT2A Q03164 1/20 0.39
NLRP3 Q96P20 1/20 0.38
SHMT2 P34897 1/20 0.38
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
NAMPT P43490 1/20 0.38
NPC1 O15118 1/20 0.38
TSHR P16473 1/20 0.38
RAB9A P51151 1/20 0.38
CXCR1 P25024 2/20 0.37
RXFP1 Q9HBX9 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6465344 0.84 EP300 (0.43) CXCR2IDO1TRPV1KMT2ANLRP3
SCHEMBL14444101 0.74 RXFP1 (0.64) KMT2AGAANPC1TSHRRAB9A
SCHEMBL8083234 0.72 EPHX1 (0.62) IDO1KMT2ANLRP3POLBNPC1
SCHEMBL8663690 0.72 ACP1 (0.62) KMT2APOLBGAANPC1TSHR
SCHEMBL7912442 0.72 CYP1A2 (0.50) CXCR2IDO1TRPV1KMT2AGAA
SCHEMBL27515121 0.72 GAA (0.56) CXCR2IDO1TRPV1KMT2APOLB
SCHEMBL10771062 0.70 TSHR (0.54) TRPV1KMT2AGAANPC1TSHR
SCHEMBL8091346 0.70 ALDH1A1 (0.56) KMT2ANLRP3POLBGAANPC1
SCHEMBL30004306 0.69 KEAP1 (0.44) IDO1KMT2ANPC1TSHRRAB9A
SCHEMBL8083304 0.69 ALDH1A1 (0.54) KMT2ANLRP3POLBGAANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0615859-B1 Thermosensitive recording material OJI PAPER CO (JP) 1998-06-03 EP claimed
US-5449657-A Sulfonyl (thio)ureas NEW OJI PAPER CO., LTD. (JP) 1995-09-12 US claimed
EP-0615859-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-09-21 EP claimed
US-11518739-B2 Sulfonamide carboxamide compounds INFLAZOME LIMITED (IE) 2022-12-06 US disclosed
US-20200216389-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2020-07-09 US disclosed
WO-2019034697-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2019-02-21 WO disclosed
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
US-20050106491-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-05-19 US disclosed
EP-1480835-A1 HEAT SENSITIVE RECORDING MATERIAL Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
EP-1480836-A1 MIXTURE OF COLOUR DEVELOPERS Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
US-6740465-B2 MULTILAYER; TRANSPARENT SUPPORT; HEAT SENSITIVE ELEMENT AND RELEASE AGENT SIPIX IMAGING, INC. 2004-05-25 US disclosed
WO-2003074284-A1 MIXTURE OF COLOUR DEVELOPERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
WO-2003074285-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
EP-1289768-A2 IMAGING MEDIA CONTAINING HEAT DEVELOPABLE PHOTOSENSITIVE MICROCAPSULES Sipix Imaging, Inc. (US) 2003-03-12 EP disclosed
US-20020155372-A1 Imaging media containing heat developable photosensitive microcapsules SIPIX IMAGING, INC. 2002-10-24 US disclosed
WO-2001092024-A2 IMAGING MEDIA CONTAINING HEAT DEVELOPABLE PHOTOSENSITIVE MICROCAPSULES SIPIX IMAGING, INC. (US) 2001-12-06 WO disclosed
EP-0615859-B1 Thermosensitive recording material OJI PAPER CO (JP) 1998-06-03 EP disclosed
US-5449657-A Sulfonyl (thio)ureas NEW OJI PAPER CO., LTD. (JP) 1995-09-12 US disclosed
EP-0615859-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-09-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200216389-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS NLRP3, NOD1, PYCARD CXCR2 116/4885IDO1 1701/4885TRPV1 43/4885
US-11518739-B2 Sulfonamide carboxamide compounds NLRP3, PYCARD, NOD1 CXCR2 153/4885IDO1 1904/4885TRPV1 50/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.