Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 4/20 | 0.37 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467918 | 0.81 | MMP2 (0.40) | MAPK1MAPTSMN1; SMN2MMP9MMP2 | |
| SCHEMBL7047938 | 0.74 | CTSS (0.39) | — | |
| SCHEMBL14276916 | 0.68 | SMN1; SMN2 (0.51) | MAPK1MAPTSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL8065479 | 0.66 | SMN1; SMN2 (0.48) | MAPK1MAPTSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL7662010 | 0.66 | TDP1 (0.43) | MAPTSMN1; SMN2RECQLALDH1A1USP2 | |
| SCHEMBL26499454 | 0.64 | NAPRT (0.49) | RECQLL3MBTL1TDP1PKMKMT2A | |
| SCHEMBL7662014 | 0.63 | KDM4E (0.55) | MAPTSMN1; SMN2ALDH1A1KMT2ALMNA | |
| SCHEMBL7743038 | 0.63 | SMN1; SMN2 (0.51) | MAPK1MAPTSMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL15045194 | 0.62 | SMN1; SMN2 (0.50) | MAPK1MAPTSMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL5419742 | 0.62 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1KMT2APTAFRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |