Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455697 | 0.79 | ALDH1A1 (0.50) | TSHRLMNAHSD17B10ALDH1A1TDP1 | |
| SCHEMBL57963 | 0.75 | HSD17B10 (0.50) | TSHRLMNAHSD17B10ALDH1A1TDP1 | |
| SCHEMBL26325 | 0.72 | TSHR (0.48) | TSHRLMNAHSD17B10ALDH1A1TDP1 | |
| SCHEMBL887743 | 0.71 | TSHR (0.48) | TSHRLMNAHSD17B10ALDH1A1TDP1 | |
| SCHEMBL1473759 | 0.71 | ALDH1A1 (0.47) | TSHRLMNAHSD17B10ALDH1A1TDP1 | |
| Water SCHEMBL28995322 | 0.71 | TSHR (0.46) | TSHRLMNAHSD17B10ALDH1A1TDP1 | |
| SCHEMBL16005234 | 0.71 | TSHR (0.46) | TSHRLMNAHSD17B10ALDH1A1TDP1 | |
| SCHEMBL146835 | 0.71 | ALDH1A1 (0.47) | TSHRLMNAHSD17B10ALDH1A1TDP1 | |
| SCHEMBL3591508 | 0.71 | ALDH1A1 (0.48) | TSHRLMNAHSD17B10ALDH1A1TDP1 | |
| SCHEMBL10383515 | 0.71 | TSHR (0.46) | TSHRLMNAHSD17B10ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050125852-A1 | Novel kinases | SUGEN, INC. | 2005-06-09 | — | — | US | disclosed |
| US-20050124794-A1 | Cell surface tropomyosin as a target of angiogenesis inhibition | MCCRAE KEITH (US) | 2005-06-09 | — | — | US | disclosed |
| US-20050118681-A1 | Novel regulatory molecule and genetic sequences encoding same | WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124794-A1 | Cell surface tropomyosin as a target of angiogenesis inhibition | TPM3, TPM4, TPD52L2 | TSHR 784/4885LMNA 3440/4885HSD17B10 3709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.