Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FAP | Q12884 | 3/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | PEPD | P12955 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 3/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14235217 | 1.00 | KLK5 (0.53) | KLK5ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL31733808 | 0.96 | FKBP1A (0.53) | KLK5ALDH1A1MEN1TSHRKMT2A | |
| Hydrochloric Acid SCHEMBL10983297 | 0.88 | KLK5 (0.44) | KLK5ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL1925210 | 0.88 | ACE (0.53) | KLK5ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL1000948 | 0.88 | ACE (0.53) | KLK5ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL14979025 | 0.88 | MEN1 (0.49) | KLK5ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL8352289 | 0.88 | MEN1 (0.49) | KLK5ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL8350809 | 0.88 | POLB (0.49) | KLK5ALDH1A1FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL8135647 | 0.87 | KLK5 (0.46) | KLK5ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL8135649 | 0.87 | KLK5 (0.46) | KLK5ALDH1A1MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120004984-A | Cyclic lactam compound and liquid phase synthesis method thereof | 上海瑗肽生化科技有限公司 | 2025-05-16 | — | — | CN | disclosed |
| CN-120004974-A | Liquid phase synthesis method of cyclic lactam compound | 上海瑗肽生化科技有限公司 | 2025-05-16 | — | — | CN | disclosed |
| US-20240016942-A1 | STAT DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2024-01-18 | — | — | US | disclosed |
| US-20240016942-A1 | STAT DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2024-01-18 | — | — | US | disclosed |
| WO-2023064991-A1 | PROCESS FOR PREPARING BICYCLIC GLYCINE-PROLINE COMPOUNDS AND MONOCYCLIC GLYCINE-PROLINE INTERMEDIATES THEREOF | NEUREN PHARMACEUTICALS LIMITED (NZ) | 2023-04-27 | — | — | WO | disclosed |
| EP-4121055-A1 | STAT DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| WO-2021188696-A1 | STAT DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| EP-2195321-B1 | 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE C | PFIZER (US) | 2016-10-19 | — | — | EP | disclosed |
| US-8999981-B2 | 3-amido-pyrrolo[3,4-C]pyrazole-5(1H, 4H,6H) carbaldehyde derivatives | PFIZER INC. (US) | 2015-04-07 | — | — | US | disclosed |
| US-20120108588-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-8114871-B2 | 3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives | PFIZER INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-20100249128-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H,4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER INC. | 2010-09-30 | — | — | US | disclosed |
| WO-2008125945-A2 | 3-AMIDO-PYRROLO [3, 4-C] PYRAZOLE-5 (1H, 4H, 6H) CARBALDEHYDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE C | PFIZER INC. (US) | 2008-10-23 | — | — | WO | disclosed |
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249128-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H,4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, PYCR1 | KLK5 1756/4885ALDH1A1 367/4885MEN1 2099/4885 |
| US-20120108588-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, PYCR1 | KLK5 1756/4885ALDH1A1 367/4885MEN1 2099/4885 |
| US-20240016942-A1 | STAT DEGRADERS AND USES THEREOF | STAT4, STAT1, STAT3 | KLK5 892/4885ALDH1A1 2465/4885MEN1 3280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.