Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.32 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762000 | 0.75 | ALDH1A1 (0.35) | KDR | |
| SCHEMBL4552449 | 0.73 | RAB9A (0.40) | KAT2B | |
| SCHEMBL4555150 | 0.72 | RAB9A (0.42) | — | |
| SCHEMBL5185734 | 0.69 | PDE7A (0.39) | EML4ALK | |
| SCHEMBL5176743 | 0.69 | PDE4B (0.39) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL6437921 | 0.69 | PDE4B (0.40) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL3422561 | 0.68 | LMNA (0.38) | KAT2BCYP3A4BRD4AXL | |
| SCHEMBL22573028 | 0.68 | KAT2B (0.41) | KAT2BPOLBCYP3A4SSTR4EHMT2 | |
| SCHEMBL4554789 | 0.65 | ALDH1A1 (0.49) | BRD4EHMT2JAK1 | |
| SCHEMBL6450335 | 0.63 | KHK (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-A2 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | claimed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | claimed |