Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5538611 | 0.84 | AKR1C1 (0.38) | PRCPSIGMAR1OPRM1AKR1C1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6926723 | 0.83 | ALDH1A1 (0.39) | PRCPSIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6472118 | 0.79 | AKR1C1 (0.38) | TACR1PRCPSIGMAR1OPRM1OPRD1 | |
| SCHEMBL518236 | 0.79 | AKR1C1 (0.40) | PRCPSIGMAR1OPRM1AKR1C1ALDH1A1 | |
| SCHEMBL4685647 | 0.78 | OPRM1 (0.33) | TACR1PRCPSIGMAR1OPRM1OPRD1 | |
| SCHEMBL11325518 | 0.74 | OPRM1 (0.41) | PRCPSIGMAR1OPRM1AKR1C1ALDH1A1 | |
| SCHEMBL2432531 | 0.69 | TSHR (0.42) | PRCPSIGMAR1OPRM1OPRD1AKR1C1 | |
| SCHEMBL2432100 | 0.68 | TSHR (0.44) | PRCPSIGMAR1OPRM1OPRD1ALDH1A1 | |
| SCHEMBL4636975 | 0.64 | AKR1C1 (0.35) | OPRM1OPRD1OPRK1AKR1C1HTT | |
| SCHEMBL11307277 | 0.64 | ALDH1A1 (0.43) | OPRM1OPRD1OPRK1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | TACR1 115/4885PRCP 3729/4885SIGMAR1 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.