Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 2/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.73 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 8/20 | 0.64 |
| ▸ | NPC1 | O15118 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 11/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | PRNP | P04156 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1886020 | 0.85 | HDAC1 (1.00) | OGG1HDAC1HDAC8HDAC6MCL1 | |
| SCHEMBL7984062 | 0.83 | HDAC1 (0.79) | OGG1HDAC1HDAC8HDAC6MCL1 | |
| SCHEMBL10148327 | 0.83 | OGG1 (0.71) | OGG1HDAC1HDAC8HDAC6MCL1 | |
| SCHEMBL8631382 | 0.83 | OGG1 (0.70) | OGG1HDAC1HDAC8HDAC6MCL1 | |
| SCHEMBL29285354 | 0.81 | OGG1 (0.69) | OGG1HDAC1HDAC8HDAC6MCL1 | |
| SCHEMBL7675240 | 0.81 | MCL1 (0.71) | OGG1HDAC1HDAC8HDAC6MCL1 | |
| SCHEMBL5935569 | 0.81 | MAPT (0.79) | OGG1HDAC1HDAC8HDAC6MCL1 | |
| SCHEMBL7088656 | 0.80 | MCL1 (0.76) | OGG1HDAC1HDAC8HDAC6MCL1 | |
| SCHEMBL25774012 | 0.80 | OGG1 (0.67) | OGG1HDAC1HDAC8HDAC6MCL1 | |
| SCHEMBL12768191 | 0.80 | HDAC1 (0.68) | OGG1HDAC1HDAC8HDAC6MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11535597-B2 | Photoreactive ligands and uses thereof | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-12-27 | — | — | US | disclosed |
| US-20200071277-A1 | PHOTOREACTIVE LIGANDS AND USES THEREOF | THE SCRIPPS RESEARCH INSTITUTE | 2020-03-05 | — | — | US | disclosed |
| US-20170038365-A1 | SMALL MOLECULE INHIBITORS OF 8-OXOGUANINE DNA GLYCOSYLASE-1 (OGG1) | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2017-02-09 | — | — | US | disclosed |
| US-20170038365-A1 | SMALL MOLECULE INHIBITORS OF 8-OXOGUANINE DNA GLYCOSYLASE-1 (OGG1) | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2017-02-09 | — | — | US | disclosed |
| US-6887863-B2 | Hydrazide and alkoxyamide angiogenesis inhibitors | ABBOTT LABORATORIES (US) | 2005-05-03 | — | — | US | disclosed |
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | disclosed |
| US-20040167126-A1 | Hydrazide and alkoxyamide angiogenesis inhibitors | ABBVIE INC. | 2004-08-26 | — | — | US | disclosed |
| US-6747052-B2 | ANTICANCER AGENTS | CYTOVIA, INC. | 2004-06-08 | — | — | US | disclosed |
| US-20030105140-A1 | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2003-06-05 | — | — | US | disclosed |
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2002102301-A2 | SUBSTITUTED INDOLE-2-CARBOXYLIC ACID BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-12-27 | — | — | WO | disclosed |
| US-20020128292-A1 | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2002-09-12 | — | — | US | disclosed |
| US-20020002152-A1 | Hydrazide and alkoxyamide angiogenesis inhibitors | ABBOTT LABORATORIES | 2002-01-03 | — | — | US | disclosed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | disclosed |
| US-5863936-A | HETEROCYCLIC ENZYME INHIBITORS AS ANTICANCER AGENTS | GERON CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |
| US-5760062-A | ANTICANCER AGENTS | GERON CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
| US-5703116-A | TREATING CANCER | GERON CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |
| US-4269846-A | BENZOHETEROCYCLIC OXADIAZOLONES AND TRIAZOLONES | USV PHARMACEUTICAL CORPORATION (US) | 1981-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11535597-B2 | Photoreactive ligands and uses thereof | CLTB, CRYAB, CRYAA | OGG1 3281/4885HDAC1 4007/4885HDAC8 3494/4885 |
| US-20020128292-A1 | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | BAD, API5, CASP2 | OGG1 2317/4885HDAC1 87/4885HDAC8 290/4885 |
| US-20030105140-A1 | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | BAD, API5, CASP2 | OGG1 2317/4885HDAC1 87/4885HDAC8 290/4885 |
| US-20040167126-A1 | Hydrazide and alkoxyamide angiogenesis inhibitors | METAP2, METAP1, ANPEP | OGG1 3275/4885HDAC1 356/4885HDAC8 1824/4885 |
| US-20200071277-A1 | PHOTOREACTIVE LIGANDS AND USES THEREOF | CLTB, CRYAB, CRYAA | OGG1 3281/4885HDAC1 4007/4885HDAC8 3494/4885 |
| US-20020002152-A1 | Hydrazide and alkoxyamide angiogenesis inhibitors | METAP2, METAP1, ANPEP | OGG1 3275/4885HDAC1 356/4885HDAC8 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.