Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254431 | 0.69 | L3MBTL1 (0.33) | SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2202292 | 0.69 | GAA (0.37) | SIGMAR1 | |
| SCHEMBL42737 | 0.67 | NOS3 (0.53) | POLB | |
| SCHEMBL11669280 | 0.66 | NOS3 (0.51) | POLB | |
| SCHEMBL11669399 | 0.66 | NOS3 (0.51) | POLB | |
| SCHEMBL11572938 | 0.65 | GAA (0.33) | — | |
| SCHEMBL1968440 | 0.65 | SLC18A2 (0.49) | — | |
| SCHEMBL11868464 | 0.64 | EPHX1 (0.43) | GRIN2BSIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6885602 | 0.63 | GRIN2B (0.45) | GRIN2BSIGMAR1EPHX1MAOAALDH1A1 | |
| SCHEMBL447548 | 0.63 | PSEN1 (0.39) | SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050033056-A1 | Hydroxylated indole derivatives and uses thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-02-10 | — | — | US | disclosed |
| WO-2003059351-A1 | HYDROXYLATED INDOLE DERIVATIVES AND USES THEREOF | EISAI CO., LTD. (JP) | 2003-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050033056-A1 | Hydroxylated indole derivatives and uses thereof | TPH2, TPH1, HTR6 | GRIN2B 558/4885SIGMAR1 262/4885PDE4A 602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.