Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 7/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480080 | 0.93 | ALDH1A1 (0.53) | ALDH1A1MAPTL3MBTL1APOBEC3AAPOBEC3G | |
| SCHEMBL9731204 | 0.83 | ALDH1A1 (0.44) | ALDH1A1MAPTL3MBTL1APOBEC3AAPOBEC3G | |
| SCHEMBL29265658 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPTL3MBTL1APOBEC3AAPOBEC3G | |
| SCHEMBL30975213 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPTL3MBTL1APOBEC3AAPOBEC3G | |
| SCHEMBL5353274 | 0.77 | TP53 (0.42) | ALDH1A1MAPTL3MBTL1TP53HPGD | |
| SCHEMBL5808527 | 0.76 | ALDH1A1 (0.69) | ALDH1A1MAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL12677912 | 0.76 | ALDH1A1 (0.69) | ALDH1A1MAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL9731029 | 0.76 | SCN9A (0.41) | ALDH1A1MAPTL3MBTL1HPGDHSD17B10 | |
| SCHEMBL9731409 | 0.75 | NTRK2 (0.45) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2326552 | 0.74 | ALDH1A1 (0.67) | ALDH1A1MAPTL3MBTL1APOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6933298-B2 | Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-08-23 | — | — | US | disclosed |
| US-20030229103-A1 | PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES AND THE USE THEREOF FOR SELECTIVELY INHIBITING COLLAGENASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-12-11 | — | — | US | disclosed |
| US-5130317-A | Immunosuppressants and fibrosuppressants for metabolism of collagen | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229103-A1 | PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES AND THE USE THEREOF FOR SELECTIVELY INHIBITING COLLAGENASES | DPYD, MMP13, MMP2 | ALDH1A1 220/4885MAPT 3588/4885L3MBTL1 4464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.