SCHEMBL648009

SCHEMBL648009

N#CC1(c2ccc(Cl)cc2)CC1

nearest known ligand 0.70

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 5/20 0.68
MAP4K4 O95819 1/20 0.49
DRD2 P14416 1/20 0.46
DRD4 P21917 1/20 0.46
DRD3 P35462 1/20 0.46
CCR1 P32246 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15862739 0.91 OPRM1 (0.64) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL2218 0.91 OPRM1 (0.64) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL1074339 0.90 OPRM1 (0.62) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL31441141 0.90 OPRM1 (0.62) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL2301089 0.88 OPRM1 (0.60) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL625403 0.86 OPRM1 (0.58) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL651535 0.86 OPRM1 (0.58) OPRM1MAP4K4DRD2DRD4DRD3
Hydrochloric Acid SCHEMBL1001869 0.85 OPRM1 (0.61) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL11073259 0.85 OPRM1 (0.57) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL20972063 0.84 OPRM1 (0.56) OPRM1MAP4K4DRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4859232-A Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes MONSANTO COMPANY (US) 1989-08-22 US claimed
WO-2025136811-A1 CHEMICAL COMPOUNDS AND USES THEREOF IDEAYA BIOSCIENCES, INC. (US) 2025-06-26 WO disclosed
EP-4305026-B1 ANTI-INFLAMMATORY CARBOXAMIDE DERIVATIVES BIOMEDCODE HELLAS SA (GR) 2025-05-07 EP disclosed
US-20240317686-A1 RORyT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) 2024-09-26 US disclosed
EP-4273129-A1 RORgammaT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-11-08 EP disclosed
EP-4273129-A1 RORgammaT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-11-08 EP disclosed
CN-116554066-A Method for synthesizing N- (hetero) aryl sulfonamide compound 陕西师范大学 2023-08-08 CN disclosed
WO-2022143771-A1 RORγT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海医药集团股份有限公司 2022-07-07 WO disclosed
WO-2022143771-A1 RORγT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海医药集团股份有限公司 2022-07-07 WO disclosed
CN-114685363-A ROR gamma t regulator, preparation method and application thereof 上海医药集团股份有限公司 2022-07-01 CN disclosed
US-6114532-A ANTICOAGULANT BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-09-05 US disclosed
WO-2000001704-A2 BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-01-13 WO disclosed
US-5998673-A ENANTIOMORPHS; BROMINATION 4-ARYL-3-FLUORO-2-BUTEN-1-OL; REACTING WITH ARYLBORONIC ACID IN PRESENCE OF A CATALYST AMERICAN CYANAMID COMPANY (US) 1999-12-07 US disclosed
WO-1999040072-A1 FIVE-MEMBERED, BENZO-CONDENSED HETEROCYCLES USED AS ANTITHROMBOTIC AGENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-08-12 WO disclosed
EP-0934283-A2 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-08-11 EP disclosed
EP-0933027-A1 Methods and compositions for protecting animals and humans against attack and infestation by arthropod and helminth parasites American Cyanamid Company (US) 1999-08-04 EP disclosed
US-5849958-A 1,4,diaryl-2-fluoro-2-butene insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1998-12-15 US disclosed
WO-1998005652-A2 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-02-12 WO disclosed
EP-0811593-A1 1,4-diaryl-2-fluoro-2-butene insecticidal and acaricidal agents American Cyanamid Company (US) 1997-12-10 EP disclosed
US-4859232-A Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes MONSANTO COMPANY (US) 1989-08-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240317686-A1 RORyT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF RORC, RORB, RORA OPRM1 3437/4885MAP4K4 3496/4885DRD2 4433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.