SCHEMBL2218

SCHEMBL2218

N#CC1(c2ccc(Cl)cc2)CCC1

nearest known ligand 0.66

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 5/20 0.64
MAP4K4 O95819 1/20 0.54
DRD2 P14416 1/20 0.44
DRD4 P21917 1/20 0.44
DRD3 P35462 1/20 0.44
MEN1 O00255 1/20 0.43
NPC1 O15118 1/20 0.43
ALDH1A1 P00352 1/20 0.43
RAB9A P51151 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CCR1 P32246 1/20 0.42
SLC6A4 P31645 2/20 0.41
SLC6A3 Q01959 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15862739 0.96 OPRM1 (0.64) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL1074339 0.94 OPRM1 (0.62) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL31441141 0.94 OPRM1 (0.62) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL648009 0.91 OPRM1 (0.68) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL14061628 0.84 OPRM1 (0.53) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL2301089 0.84 OPRM1 (0.60) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL625403 0.82 OPRM1 (0.58) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL651535 0.82 OPRM1 (0.58) OPRM1MAP4K4DRD2DRD4DRD3
Hydrochloric Acid SCHEMBL1001869 0.81 OPRM1 (0.61) OPRM1MAP4K4DRD2DRD4DRD3
SCHEMBL11073259 0.81 OPRM1 (0.57) OPRM1MAP4K4DRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 239 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119060088-A Methyl parathion hapten, sibutramine hapten, methyl parathion-sibutramine artificial antigen, antibody and detection kit 天地壹号饮料股份有限公司 2024-12-03 CN claimed
EP-4305026-B1 ANTI-INFLAMMATORY CARBOXAMIDE DERIVATIVES BIOMEDCODE HELLAS SA (GR) 2025-05-07 EP disclosed
CN-119060088-A Methyl parathion hapten, sibutramine hapten, methyl parathion-sibutramine artificial antigen, antibody and detection kit 天地壹号饮料股份有限公司 2024-12-03 CN disclosed
US-20240317686-A1 RORyT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) 2024-09-26 US disclosed
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2024-05-30 US disclosed
EP-4288412-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME Rappta Therapeutics Oy (FI) 2023-12-13 EP disclosed
EP-4273129-A1 RORgammaT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-11-08 EP disclosed
EP-4273129-A1 RORgammaT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-11-08 EP disclosed
CN-114773136-B Method for synthesizing aromatic amine 陕西师范大学 2023-06-16 CN disclosed
EP-3362445-B1 OXADIAZOLE AMINE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME CHONG KUN DANG PHARMACEUTICAL CORP (KR) 2023-01-25 EP disclosed
US-4522828-A CYCLOBUTYLALKYLAMINE COMPOUNDS, ANTIDEPRESSANTS THE BOOTS COMPANY PLC (GB) 1985-06-11 US disclosed
EP-0111994-A1 (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents The Boots Company PLC (GB) 1984-06-27 EP disclosed
EP-0108488-A1 (1-Arylcyclobutyl) (heterocyclyl) methylamine compounds, their preparation and their use as therapeutic agents The Boots Company PLC (GB) 1984-05-16 EP disclosed
US-4443449-A Arylcyclobutylalkylamines and anti-depression composition and methods using same THE BOOTS COMPANY LIMITED (GB) 1984-04-17 US disclosed
US-4355042-A A CYCLOBUTANE CARBOXYLIC ACID DERIVATIVE COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) 1982-10-19 US disclosed
US-4348409-A MITICIDES, NEMATOCIDES COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) 1982-09-07 US disclosed
US-4339458-A HALOCYCLOBUTANECARBOXYLATES COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) 1982-07-13 US disclosed
EP-0002620-B1 CYCLOALKYL CARBOXYLIC ESTERS, INSECTICIDAL COMPOSITIONS CONTAINING THEM, AND METHODS FOR THEIR PREPARATION COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 1981-11-25 EP disclosed
US-4235926-A DERIVATIVES OF CYCLOBUTANE COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) 1980-11-25 US disclosed
EP-0002620-A1 Cycloalkyl carboxylic esters, insecticidal compositions containing them, and methods for their preparation COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 1979-06-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240317686-A1 RORyT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF RORC, RORB, RORA OPRM1 3437/4885MAP4K4 3496/4885DRD2 4433/4885
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME PPM1A, PPP2CA, PPP3CA OPRM1 4413/4885MAP4K4 794/4885DRD2 4726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.