Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482401 | 0.95 | MAPT (0.50) | MAPTLMNANPSR1HTR1AHTR7 | |
| SCHEMBL10670677 | 0.84 | MAPT (0.46) | MAPTLMNANPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21553853 | 0.81 | ALDH1A1 (0.50) | MAPTLMNANPSR1ALDH1A1MEN1 | |
| SCHEMBL10860851 | 0.79 | ALDH1A1 (0.57) | MAPTLMNANPSR1HTR1AHTR7 | |
| SCHEMBL8635829 | 0.77 | MAPT (0.57) | MAPTLMNAHTR1ANPC1RAB9A | |
| SCHEMBL5175516 | 0.77 | HTR1A (0.49) | LMNAHTR1AHTR7ALDH1A1CYP2C9 | |
| SCHEMBL27979649 | 0.77 | TDP1 (0.59) | NPC1SMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL27981599 | 0.77 | GPR119 (0.49) | MAPTLMNANPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4107060 | 0.77 | TSHR (0.36) | LMNAALDH1A1TSHR | |
| SCHEMBL8634727 | 0.77 | HRH3 (0.55) | MAPTLMNAHTR1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872850-B2 | Small molecule inhibitors of secretion of proteins encoded by ARE-mRNAs | MESSAGE PHARMACEUTICALS (US) | 2005-03-29 | — | — | US | disclosed |
| WO-2002083842-A9 | SMALL MOLECULE INHIBITORS OF SECRETION OF PROTEINS ENCODED BY ARE-MRNAS | MESSAGE PHARMACEUTICALS INC (US) | 2004-04-29 | — | — | WO | disclosed |
| US-20030199453-A1 | Small molecule inhibitors of secretion of proteins encoded by ARE-mRNAs | S. R. ONE, LIMITED | 2003-10-23 | — | — | US | disclosed |
| WO-2002083842-A2 | SMALL MOLECULE INHIBITORS OF SECRETION OF PROTEINS ENCODED BY ARE-MRNAS | MESSAGE PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199453-A1 | Small molecule inhibitors of secretion of proteins encoded by ARE-mRNAs | ASF1A, IGF2BP1, SERBP1 | MAPT 3875/4885LMNA 3268/4885NPSR1 2679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.