Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088459 | 0.81 | ALOX5 (0.41) | ALDH1A1KDM4ELMNACYP1A2CYP2C19 | |
| SCHEMBL6698677 | 0.78 | ALDH1A1 (0.35) | ALDH1A1KDM4EGAALMNACYP2C19 | |
| SCHEMBL7990577 | 0.77 | KMT2A (0.47) | ALDH1A1KDM4EGAALMNANPC1 | |
| SCHEMBL6866131 | 0.76 | MEN1 (0.48) | ALDH1A1NPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL6859753 | 0.76 | MEN1 (0.48) | ALDH1A1NPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL7156234 | 0.75 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNANPC1HDAC3 | |
| SCHEMBL7431514 | 0.75 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNANPC1HDAC3 | |
| SCHEMBL7476442 | 0.74 | ALDH1A1 (0.37) | ALDH1A1KDM4ENPC1HDAC1SMN1; SMN2 | |
| SCHEMBL6882657 | 0.72 | L3MBTL1 (0.42) | ALDH1A1KDM4EHTTSMN1; SMN2KMT2A | |
| SCHEMBL6790765 | 0.71 | ALDH1A1 (0.52) | ALDH1A1KDM4EGAALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908919-B2 | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION (US) | 2005-06-21 | — | — | US | claimed |