Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6486783 | 0.93 | SIGMAR1 (0.37) | HRH3SIGMAR1KEAP1SMN1; SMN2ALOX15 | |
| SCHEMBL6487786 | 0.85 | HRH3 (0.39) | HRH3SIGMAR1SMN1; SMN2MAPT | |
| SCHEMBL1886906 | 0.82 | — | — | |
| SCHEMBL1480820 | 0.78 | KEAP1 (0.54) | SIGMAR1KEAP1SMN1; SMN2ALOX15 | |
| SCHEMBL13692453 | 0.77 | — | — | |
| SCHEMBL13692574 | 0.77 | HRH3 (0.65) | HRH3SIGMAR1SMN1; SMN2MAPT | |
| SCHEMBL651943 | 0.76 | GNAO1 (0.52) | SIGMAR1 | |
| SCHEMBL7513277 | 0.76 | HRH3 (0.39) | HRH3MAPT | |
| SCHEMBL6485650 | 0.76 | HRH3 (0.39) | HRH3SMN1; SMN2MAPT | |
| SCHEMBL6475492 | 0.76 | HTR1A (0.31) | SIGMAR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962911-B2 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2005-11-08 | — | — | US | disclosed |
| EP-1257553-B1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO LTD (KR) | 2004-05-26 | — | — | EP | disclosed |
| EP-1257553-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK Chemicals Co., Ltd. (KR) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001060825-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO., LTD. (KR) | 2001-08-23 | — | — | WO | disclosed |