Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063303 | 0.87 | PYGL (0.56) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL5225716 | 0.82 | NR4A2 (0.67) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL5067961 | 0.77 | ADAM17 (0.64) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL15636289 | 0.74 | NR4A2 (0.70) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL25305901 | 0.74 | NR4A2 (0.64) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL30457500 | 0.74 | NR4A2 (0.64) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL1612772 | 0.72 | LMNA (0.68) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL1613529 | 0.71 | NR4A2 (0.60) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL5739049 | 0.71 | GABRA1 (0.82) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL3130989 | 0.70 | NR4A2 (0.52) | NR4A2GABRA1GABRB2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009817-A1 | Substituted heteroaryls | INSTITUTES FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009817-A1 | Substituted heteroaryls | PTPRS, PTPRO, PTPRR | NR4A2 4086/4885GABRA1 2797/4885GABRB1 1275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.