Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.37 |
| ▸ | MAP2 | P11137 | 9/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | ATP4A | P20648 | 1/20 | 0.34 |
| ▸ | ATP4B | P51164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487432 | 1.00 | SIRT1 (0.37) | SIRT1MAP2BAZ2BMAPTKDM4E | |
| SCHEMBL6488069 | 0.88 | ALDH1A1 (0.35) | SIRT1BAZ2BMAPTKDM4EALDH1A1 | |
| SCHEMBL6500149 | 0.88 | MAP2 (0.36) | MAP2BAZ2BMAPTALDH1A1MEN1 | |
| SCHEMBL6500147 | 0.88 | MAP2 (0.36) | MAP2BAZ2BMAPTALDH1A1MEN1 | |
| SCHEMBL6488072 | 0.88 | ALDH1A1 (0.35) | SIRT1BAZ2BMAPTKDM4EALDH1A1 | |
| SCHEMBL6491882 | 0.87 | SIRT1 (0.37) | SIRT1BAZ2BMAPTKDM4EALDH1A1 | |
| SCHEMBL6491884 | 0.87 | SIRT1 (0.37) | SIRT1BAZ2BMAPTKDM4EALDH1A1 | |
| SCHEMBL6494583 | 0.86 | MAPT (0.38) | MAPTKDM4EALDH1A1GAANPSR1 | |
| SCHEMBL6494579 | 0.86 | MAPT (0.38) | MAPTKDM4EALDH1A1GAANPSR1 | |
| SCHEMBL6490196 | 0.82 | BUB1 (0.37) | MAPTKDM4EGAALMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951881-B2 | (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-10-04 | — | — | US | disclosed |
| US-20030232843-A1 | (1-Substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232843-A1 | (1-Substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR1A | SIRT1 1181/4885MAP2 1097/4885BAZ2B 3444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.