Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.56 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | RXRB | P28702 | 3/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3168574 | 0.84 | METAP2 (0.54) | FOLH1PPARAHSD17B10SMN1; SMN2PTPN11 | |
| SCHEMBL6491569 | 0.82 | FOLH1 (0.55) | FOLH1AKR1C2HSD17B10RXRARXRB | |
| SCHEMBL3737187 | 0.82 | FOLH1 (0.71) | FOLH1HSD17B10SMN1; SMN2PTPN11RAB9A | |
| SCHEMBL6498615 | 0.81 | FOLH1 (0.54) | FOLH1HSD17B10SMN1; SMN2PTPN11RAB9A | |
| SCHEMBL6491531 | 0.81 | CYP2C8 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6488790 | 0.80 | AKR1C3 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6501365 | 0.80 | PTPN11 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3909846 | 0.79 | CYP2C8 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6492505 | 0.79 | CYP2C8 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6500539 | 0.78 | AKR1C3 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050038035-A1 | Heterocyclic amide compounds as apolipoprotein b inhibitors | DAISO CO., LTD. (JP) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038035-A1 | Heterocyclic amide compounds as apolipoprotein b inhibitors | APOB, APOL1, CTRB2 | PSEN1 301/4885PSEN2 311/4885APH1B 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.