Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032563 | 0.89 | ALDH1A1 (0.47) | LMNAKDM4ESMN1; SMN2ALDH1A1PTGER1 | |
| SCHEMBL5034980 | 0.88 | KDM4E (0.47) | LMNAKDM4EKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5035778 | 0.88 | RAB9A (0.46) | LMNAKDM4EKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5032539 | 0.87 | KDM4E (0.43) | KDM4ERAB9ASMN1; SMN2ALDH1A1HTT | |
| Propylamine SCHEMBL6488547 | 0.82 | KDM4E (0.46) | KDM4ERAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL5035889 | 0.82 | KDM4E (0.43) | LMNAKDM4EKMT2ARAB9ASMN1; SMN2 | |
| Methylethylamine SCHEMBL6488540 | 0.82 | KDM4E (0.43) | LMNAKDM4EKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5038951 | 0.80 | KDM4E (0.43) | LMNAKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6491939 | 0.79 | MAPT (0.40) | LMNAKDM4EKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5032680 | 0.78 | CES2 (0.41) | LMNAKDM4ESMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | disclosed |
| US-20050153962-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153962-A1 | Thiazole derivatives | CNR1, CNR2, GPR119 | LMNA 4010/4885KDM4E 3200/4885KMT2A 3489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.