Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.34 |
| ▸ | MME | P08473 | 4/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652578 | 0.95 | AGTR1 (0.34) | RARARARBRARGAGTR1MME | |
| SCHEMBL650059 | 0.89 | AGTR1 (0.37) | AGTR1MME | |
| SCHEMBL652331 | 0.88 | DRD2 (0.35) | AGTR1 | |
| SCHEMBL648189 | 0.88 | DRD2 (0.34) | AGTR1 | |
| SCHEMBL652770 | 0.87 | TLR8 (0.35) | AGTR1F2F7F3 | |
| SCHEMBL650291 | 0.86 | DRD2 (0.33) | MEN1KMT2AAGTR1 | |
| SCHEMBL651121 | 0.82 | MEN1 (0.34) | MEN1KMT2AAGTR1 | |
| SCHEMBL648999 | 0.82 | ADORA3 (0.37) | RARARARBRARGMEN1KMT2A | |
| SCHEMBL648906 | 0.80 | HDAC1 (0.39) | KMT2AAGTR1TLR7HDAC1 | |
| SCHEMBL650281 | 0.80 | AGTR1 (0.40) | AGTR1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |