Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650087 | 0.93 | ADORA3 (0.35) | AGTR1MEN1KMT2AADORA2B | |
| SCHEMBL652331 | 0.93 | DRD2 (0.35) | DRD2TBXA2RAGTR1TLR8TRIM24 | |
| SCHEMBL648189 | 0.92 | DRD2 (0.34) | DRD2TBXA2RAGTR1TLR8TRIM24 | |
| SCHEMBL652770 | 0.91 | TLR8 (0.35) | DRD2TBXA2RAGTR1TLR8TRIM24 | |
| SCHEMBL652578 | 0.90 | AGTR1 (0.34) | DRD2TBXA2RAGTR1TLR8 | |
| SCHEMBL651121 | 0.90 | MEN1 (0.34) | DRD2TBXA2RAGTR1TLR8MEN1 | |
| SCHEMBL648905 | 0.86 | RARA (0.35) | AGTR1MEN1KMT2A | |
| SCHEMBL648999 | 0.85 | ADORA3 (0.37) | AGTR1MEN1KMT2AADORA2B | |
| SCHEMBL653481 | 0.83 | MERTK (0.34) | DRD2TBXA2RAGTR1ADORA2B | |
| SCHEMBL650059 | 0.83 | AGTR1 (0.37) | AGTR1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |