SCHEMBL6489966

SCHEMBL6489966

CCOC(=O)CCCOc1ccc(NC(C)=O)c(NCc2ccc(N(C)C(=O)OCC)cc2Cl)c1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.37
PDK2 Q15119 2/20 0.36
PDE3B Q13370 1/20 0.36
PDE3A Q14432 1/20 0.36
P2RY12 Q9H244 1/20 0.36
TDP1 Q9NUW8 2/20 0.35
PABPC1 P11940 1/20 0.35
CNR1 P21554 1/20 0.35
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
PDE4D Q08499 1/20 0.34
DRD2 P14416 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
LTA4H P09960 1/20 0.33
PLA2G2A P14555 1/20 0.33
PPARG P37231 1/20 0.33
CYSLTR2 Q9NS75 1/20 0.33
CYSLTR1 Q9Y271 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6829611 0.93 FFAR4 (0.39) TDP1DRD2PPARG
SCHEMBL6497406 0.88 BRD4 (0.41) BRD4PDK2PDE3BPDE3AP2RY12
SCHEMBL6489796 0.87 MAPT (0.42) BRD4PDK2PDE3BPDE3AP2RY12
SCHEMBL6829609 0.79 FFAR1 (0.40) BRD4TDP1L3MBTL1
SCHEMBL6501452 0.76 IDO1 (0.41) BRD4PDK2PDE3BPDE3AP2RY12
SCHEMBL6491102 0.74 PDE3B (0.43) BRD4PDE3BPDE3AP2RY12PLA2G2A
SCHEMBL6487898 0.74 MAPT (0.42) BRD4PDK2PDE3BPDE3AP2RY12
SCHEMBL6496310 0.74 THRB (0.41) DRD2L3MBTL1
SCHEMBL6489028 0.73 L3MBTL1 (0.47) PDK2L3MBTL1PPARG
SCHEMBL6487794 0.73 EPHX2 (0.42) BRD4PDK2PDE3BPDE3AP2RY12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11112718-B2 Electrophotographic member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2021-09-07 US disclosed
US-20190094741-A1 ELECTROPHOTOGRAPHIC MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2019-03-28 US disclosed
US-9511147-B2 Interpolymer network delivery system RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2016-12-06 US disclosed
US-20140308331-A1 INTERPOLYMER NETWORK DELIVERY SYSTEM RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2014-10-16 US disclosed
US-20120316255-A1 STRENGTH-IMPROVING AGENT FOR PRODUCTION OF POLYURETHANE FOAM SANYO CHEMICAL INDUSTRIES, LTD. (JP) 2012-12-13 US disclosed
US-6855742-B2 Agents for reducing the force-to-crush (FTC) of high support flexible foams BAYER ANTWERP, N.V. (BE) 2005-02-15 US disclosed
US-20050014812-A1 Benzimidazole compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2005-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120316255-A1 STRENGTH-IMPROVING AGENT FOR PRODUCTION OF POLYURETHANE FOAM F2, F12, PTH1R BRD4 3471/4885PDK2 1534/4885PDE3B 3023/4885
US-20050014812-A1 Benzimidazole compounds SLC5A1, SLC5A2, G6PD BRD4 130/4885PDK2 128/4885PDE3B 411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.